3282-56-2

Usage

Purification Methods

Recrystallise it three times by partially freezing a mixture of the mono-nitro isomers, then recrystallise it twice from MeOH and dry it in vacuo [Brown J Am Chem Soc 81 3232 1959]. [Beilstein 5 H 418, 5 I 203, 5 II 321, 5 III 943, 5 IV 1052.]

InChI:InChI=1/C10H13NO2/c1-10(2,3)8-4-6-9(7-5-8)11(12)13/h4-7H,1-3H3

Upstream product

• 253185-03-4 tert-butylbenzene 
• 1012-72-2 1,4-di-tert-butylbenzene 
• 598-58-3 methyl nitrate 
• 19099-48-0 1,1-bis(4-t-butylphenyl)methane 
• 108-24-7 acetic anhydride 
• 558-17-8 tert-Butyl iodide 
• 98-95-3 nitrobenzene 
• 4627-22-9 bis(4-tert-butylphenyl)amine 
• 769-92-6 4-tert-Butylaniline 
• 7732-18-5 water 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 507-20-0 tertiary butyl chloride 

Downstream Products

• 769-92-6 4-tert-Butylaniline 
• 6310-17-4 2-bromo-1-tert-butyl-4-nitrobenzene 
• 52756-38-4 1-(tert-butyl)-2-chloro-4-nitrobenzene 
• 4160-54-7 1-tert-butyl-2,4-dinitrobenzene 
• 7775-84-0 4-tert-butyl-N²-(4-tert-butyl-phenyl)-o-phenylenediamine 
• 7775-78-2 1,2-di(p-tert-butylphenyl)hydrazine 
• 61994-99-8 1,2-bis(4-(tert-butyl)phenyl)diazene oxide 
• 7775-81-7 4,4′-di(tert-butyl)azobenzene 
• 13252-73-8 N-(4-tert-Butylphenyl)hydroxylamine 
• 89278-05-7 (5-tert.-Butyl-2-nitrophenyl)acetonitrile 
• 89303-14-0 2-Benzenesulfonylmethyl-4-tert-butyl-1-nitro-benzene 
• 1943-67-5 4-(t-butyl)phenyl isocyanate 
• 142564-53-2 5-(tert-butyl)-2-nitroaniline 
• 777861-95-7 C₃₂H₃₇N₂P 

Relevant academic research and scientific papers

Brightly shining nanoparticles: Lipophilic perylene bisimides in aqueous phase

The dispersion of lipophilic perylene bisimides down to nanoparticle dimensions opens the aqueous phase to these highly fluorescent, water insoluble materials. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Photoinduced Iron-Catalyzed ipso-Nitration of Aryl Halides via Single-Electron Transfer

A photoinduced iron-catalyzed ipso-nitration of aryl halides with KNO2 has been developed, in which aryl iodides, bromides, and some of aryl chlorides are feasible. The mechanism investigations show that the in situ formed iron complex by FeSO4, KNO2, and 1,10-phenanthroline acts as the light-harvesting photocatalyst with a longer lifetime of the excited state, and the reaction undergoes a photoinduced single-electron transfer (SET) process. This work represents an example for the photoinduced iron-catalyzed Ullmann-type couplings.

N-Nitroheterocycles: Bench-Stable Organic Reagents for Catalytic Ipso-Nitration of Aryl- And Heteroarylboronic Acids

Photocatalytic and metal-free protocols to access various aromatic and heteroaromatic nitro compounds through ipso-nitration of readily available boronic acid derivatives were developed using non-metal-based, bench-stable, and recyclable nitrating reagents. These methods are operationally simple, mild, regioselective, and possess excellent functional group compatibility, delivering desired products in up to 99% yield.

Base promoted peroxide systems for the efficient synthesis of nitroarenes and benzamides

A useful and efficient approach for the synthesis of nitroarenes from several aromatic amines (including heterocycles) using peroxide and base has been developed. This oxidative reaction is very easy to handle and afforded the products in good yields. Formation of benzamides from benzylamine was also successfully carried out with this metal-free catalytic system in good to excellent yields.

Nucleophilic Iron Complexes in Proton-Transfer Catalysis: An Iron-Catalyzed Dimroth Cyclocondensation

The nucleophilic iron complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) is an active catalyst in C?H-amination but also in proton-transfer catalysis. Herein, we describe the successful use of this complex as a proton-transfer catalyst in the cyclocondensation reaction between azides and ketones to the corresponding 1,2,3-triazoles. Cross-experiments indicate that the proton-transfer catalysis is significantly faster than the nitrene-transfer catalysis, which would lead to the C?H amination product. An example of a successful sequential Dimroth triazole–indoline synthesis to the corresponding triazole-substituted indolines is presented.

Synthesis of nitroolefins and nitroarenes under mild conditions

1,3-Disulfonic acid imidazolium nitrate {[Dsim]NO3} was prepared and characterized as a new ionic liquid and nitrating agent for the ipso-nitration of various arylboronic acids and nitro-Hunsdiecker reaction of different α,β-unsaturated acids and benzoic acid derivatives, by in situ generation of NO2 to give various nitroarenes and nitroolefins without using any cocatalysts and solvents under mild conditions.

Transition-metal-free synthesis of thiocyanato- or nitro-arenes through diaryliodonium salts

A transition-metal-free approach to facile synthesis of thiocyanato- and nitro-arenes was developed from KSCN (potassiumthiocyanate) or NaNO2with diaryliodonium salts in good yields under mild conditions. The reaction was compatible with a variety of sensitive functional substituents such as halides and nitro and ester groups. The usefulness of arylation products has been realized. (Formula Present).

One-Pot C?H Functionalization of Arenes by Diaryliodonium Salts

A transition-metal-free, mild, and highly regioselective synthesis of nitroarenes from arenes has been developed. The products are obtained in a sequential one-pot reaction by nitration of iodine(III) reagents with two carbon ligands, which are formed in situ from iodine(I). This novel concept has been extended to formation of aryl azides, and constitutes an important step towards catalytic reactions with these hypervalent iodine reagents. An efficient nitration of isolated diaryliodonium salts has also been developed, and the mechanism is proposed to proceed by a [2,2] ligand coupling pathway.

Regioselective nitration of aromatics with nanomagnetic solid superacid SO42-/ZrO2-MxOy-Fe 3O4 and its theoretical studies

A series of micro- and nanosulfated zirconia loaded on Fe3O 4 or other metal oxides (SO42-/ZrO 2-MxOy-Fe3O4 (M=Ti 4+, V5+, and Zn2+)) was prepared, characterized, and used in nitration. The nitration conditions with these solid superacids were then optimized to achieve the best regioselectivity and improve the performances of the catalysts as well. In the experimental results, SZTF (SO42-/ZrO2-TiO2-Fe 3O4) showed excellent catalytic activity and it increased the surface area of SO42-/ZrO2 by up to 15 %. The increase not only facilitated the generation of NO2+, but also provided more opportunities for metal ions to interact with aromatic compounds. With chlorobenzene as substrate, theoretical research on its geometric parameters, electron clouds, and electron spin density was used to investigate the interaction between transition metals and chlorobenzene.

Preparation of heteropoly acid based amphiphilic salts supported by nano oxides and their catalytic performance in the nitration of aromatics

A series of Keggin heteropoly acid anion based amphiphilic salts supported by nano oxides were synthesized and used as catalysts in the nitration of aromatic compounds with HNO3. The reaction conditions in the nitration of toluene were optimized and both 92.6% conversion and good para selectivity (ortho:para = 1.09) were obtained.