103275-75-8Relevant articles and documents
A synthetic BNC105 method
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, (2017/08/25)
The invention relates to a method for compounding BNC 105, which uses o-vanillin and 3,4,5- trimethoxy-benzaldehyde as starting materials. The o-vanillin is subjected to hydroxy protection and aldehyde oxidation to be hydrolyzed into phenol, and the pheno
CHEMICAL PROCESSES FOR THE MANUFACTURE OF SUBSTITUTED BENZOFURANS
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, (2012/02/02)
The present invention relates to the scaled-up synthesis of biologically active compounds which display useful therapeutic activity in treating proliferative disorders. In particular the invention relates to process methods for the kilogram scale synthesi
An efficient synthesis and substitution of 3-aroyl-2-bromobenzo[b]furans
Gill, Gurmit S.,Grobelny, Damian W.,Chaplin, Jason H.,Flynn, Bernard L.
, p. 1131 - 1134 (2008/09/18)
(Chemical Equation Presented) A convenient method for the synthesis of 2-bromo-3-aroyl-benzo[b]furans from readily accessible precursors has been developed. The 2-bromo group has been employed as a versatile synthetic handle in both palladium-mediated cou
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent
Su, Chung-Ren,Shen, Yuh-Chiang,Kuo, Ping-Chung,Leu, Yann-Lii,Damu, Amooru G.,Wang, Yea-Hwey,Wu, Tian-Shung
, p. 6155 - 6160 (2007/10/03)
Total synthesis of viscolin, an anti-inflammatory 1,3-diphenylpropane isolated from Viscum coloratum, employing the Wittig reaction is reported. Key steps in the synthesis of viscolin depend on the selection of protecting groups to maintain the para hydroxyl group that is the most critical chemical structure influencing the biological activity of viscolin and the utilization of microwave-assisted Wittig olefination reaction. Anti-inflammatory potency of the synthetic viscolin, its precursor product 16, and its analogue 17, through their effects on reactive oxygen species (ROS), nitric oxide (NO), and pro-inflammatory cytokine production in leukocytes and microglial cells were evaluated. Excellent inhibition of ROS and NO production in inflammatory cells could confer the synthetic viscolin to be a potent anti-inflammatory agent for the treatment of oxidative stress-induced diseases.