2-Isopropoxy-3-methoxyphenol

Base Information

• Chemical Name: 2-Isopropoxy-3-methoxyphenol
• CAS No.: 103275-75-8
• Molecular Formula: C10H14 O3
• Molecular Weight: 182.219
• Hs Code.: 2909500000
• DSSTox Substance ID: DTXSID30698979
• Wikidata: Q82629609
• Mol file: 103275-75-8.mol

Synonyms:2-Isopropoxy-3-methoxyphenol;103275-75-8;3-methoxy-2-propan-2-yloxyphenol;3-METHOXY-2-ISOPROPYLOXYPHENOL;DTXSID30698979;MB25436;3-Methoxy-2-[(propan-2-yl)oxy]phenol

Chemical Property of 2-Isopropoxy-3-methoxyphenol

Chemical Property:

• PSA: 38.69000
• LogP: 2.18800
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 147

Purity/Quality:

98%min ^*data from raw suppliers

2-Isopropoxy-3-methoxyphenol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)OC1=C(C=CC=C1OC)O

Technology Process of 2-Isopropoxy-3-methoxyphenol

There total 4 articles about 2-Isopropoxy-3-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-isopropoxy-3-methoxy-benzaldehyde (75792-35-7) → 2-isopropoxy-3-methoxyphenol (103275-75-8)

Guidance literature:

2-isopropoxy-3-methoxy-benzaldehyde; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; Industry scale;

With water; sodium hydroxide; In methanol; at 20 ℃; for 2h; Industry scale;

Reference yield:

formic acid 2-isopropoxy-3-methoxy-phenyl ester → 2-isopropoxy-3-methoxyphenol (103275-75-8)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/j.bmcl.2006.09.046

Reference yield:

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 2-isopropoxy-3-methoxyphenol (103275-75-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / K₂CO₃ / dimethylformamide

2: m-CPBA / CH₂Cl₂

3: NaOH / methanol

With sodium hydroxide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; 2: Baeyer-Villiger oxidation;

DOI:10.1016/j.bmcl.2006.09.046

upstream raw materials:

2-isopropoxy-3-methoxy-benzaldehyde

3-methoxy-2-hydroxybenzaldehyde

Downstream raw materials:

Kohlensaeure-bis-(3-methoxy-2-isopropyloxy-phenylester)

1-Benzyloxy-2-isopropoxy-3-methoxy-benzene

2-benzyloxy-6-methoxy-[1,4]benzoquinone

2-benzyloxy-6-methoxy-hydroquinone