Computer aided modeling guided the design of a series of diarylimidazole compounds (11-22) intended to interact with both the ATP and adjacent allosteric binding domains of B-RAF kinase. Their ability to inhibit the function of B-RAF kinase and intracellular ERK1/2 phosphorylation were evaluated.
Wolin, Ronald L.,Bembenek, Scott D.,Wei, Jianmei,Crawford, Shelby,Lundeen, Katherine,Brunmark, Anders,Karlsson, Lars,Edwards, James P.,Blevitt, Jonathan M.
p. 2825 - 2829
(2008/12/22)
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