1034266-14-2Relevant articles and documents
3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
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Page/Page column 158; 159; 172, (2014/09/29)
The invention is directed to a formula (I), or a pharmamceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
Haloalkyl-substituted amides as insecticides and acaricides
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Page/Page column 55-56, (2011/05/08)
The present invention relates to halogen-substituted amide derivatives of the general formula (I)in which R1 to R6, Q1 to Q8, A, V, W, X, Y, n and m are each defined as described in the descriptionand to a process for preparation thereof and to the use th
CB1 RECEPTOR MODULATORS
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Page/Page column 52, (2008/12/06)
Compounds of formula (I) suppress the normal signalling activity CB1 receptors, and are thus useful in the treatment of diseases or conditions which are mediated by CB1 receptor signalling activity, such as treatment of obesity and overweight, prevention
Efficient synthesis of chiral phenethylamines: preparation, asymmetric hydrogenation, and mild deprotection of ene-trifluoroacetamides
Allwein, Shawn P.,McWilliams, J. Christopher,Secord, Elizabeth A.,Mowrey, Dale R.,Nelson, Todd D.,Kress, Michael H.
, p. 6409 - 6412 (2007/10/03)
A mild and efficient route to enantioenriched aryl alkyl amines from ketones has been developed. The first successful synthesis and asymmetric hydrogenation of ene-trifluoroamides from oximes gave highly enantioenriched trifluoroacetamides (94-98% ee). The corresponding phenethyl amides are liberated under mild conditions (K2CO3, MeOH/H2O). In addition, a new application of Josiphos ligands toward the asymmetric hydrogenation of both ene-acetamides and ene-trifluoroacetamides was discovered.