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CAS

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1034895-42-5

9-ING-41 is a small molecule compound that acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) and exhibits antitumor activity. It has the ability to induce apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

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  • 1034895-42-5 Structure

  • Basic information

    1. Product Name: 9-ING-41
    2. Synonyms:
    3. CAS NO:1034895-42-5
    4. Molecular Formula:
    5. Molecular Weight: 404.354
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1034895-42-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 9-ING-41(CAS DataBase Reference)
    10. NIST Chemistry Reference: 9-ING-41(1034895-42-5)
    11. EPA Substance Registry System: 9-ING-41(1034895-42-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1034895-42-5(Hazardous Substances Data)

1034895-42-5 Usage

Uses

Used in Oncology:
9-ING-41 is used as an antitumor agent for its ability to induce apoptosis and cell cycle arrest in cancer cells. It has been shown to effectively inhibit tumor growth in xenografted rat models.
Used in Pharmaceutical Industry:
9-ING-41 is used as a lead compound in the development of new drugs targeting GSK-3, a key enzyme involved in various cellular processes and associated with several diseases, including cancer.
Used in Drug Discovery and Development:
9-ING-41 serves as a valuable tool in drug discovery and development for its potential to target GSK-3 and modulate its activity, offering a promising avenue for the treatment of cancer and other diseases.

In vivo

9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.

In vitro

9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells.9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

Check Digit Verification of cas no

The CAS Registry Mumber 1034895-42-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,4,8,9 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1034895-42:
(9*1)+(8*0)+(7*3)+(6*4)+(5*8)+(4*9)+(3*5)+(2*4)+(1*2)=155
155 % 10 = 5
So 1034895-42-5 is a valid CAS Registry Number.

1034895-42-5Downstream Products

1034895-42-5Relevant articles and documents

SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H-[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE

-

, (2019/05/10)

The present disclosure relates to solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl) pyrrole-2,5-dione, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof in treating disease.

SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE

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, (2019/02/25)

The present disclosure relates to solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof in treating disease.

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