267-48-1

Basic information

• Product Name: 5,6-METHYLENEDIOXYINDOLE
• Synonyms: 5h-1,3-dioxolo(4,5-f)indole;5,6-METHYLENEDIOXYINDOLE;5-6-methylenedioxyindole tan crystals;5H-[1,3]dioxolo[4,5-f]indol
• CAS NO: 267-48-1
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• EINECS: 205-976-3
• Product Categories: Indoles and derivatives;Building Blocks;Heterocyclic Building Blocks;Indoles
• Mol File: 267-48-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 110 °C
• Boiling Point: 350.4°Cat760mmHg
• Flash Point: 134.9°C
• Appearance: tan/
• Density: 1.47g/cm³
• Vapor Pressure: 0.000244mmHg at 25°C
• Refractive Index: 1.72
• Storage Temp.: 2-8°C
• PKA: 16.93±0.20(Predicted)
• CAS DataBase Reference: 5,6-METHYLENEDIOXYINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-METHYLENEDIOXYINDOLE(267-48-1)
• EPA Substance Registry System: 5,6-METHYLENEDIOXYINDOLE(267-48-1)

Safety Data

• Statements: 20/21/22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: JI4650000
• Hazardous Substances Data: 267-48-1(Hazardous Substances Data)

Usage

General Description

5,6-METHYLENEDIOXYINDOLE is a chemical compound with the molecular formula C9H9NO2. It is a derivative of indole with a methylenedioxy group (O-CH2-O) attached to the 5 and 6 positions of the ring. 5,6-METHYLENEDIOXYINDOLE is known to have psychoactive properties and is also used as a precursor in the synthesis of various psychoactive substances. It acts as a serotonin receptor agonist and has been studied for its potential therapeutic effects on depression, anxiety, and other mood disorders. Additionally, it has been investigated for its potential use in the treatment of neurodegenerative diseases and as a tool for studying serotonin receptor function. However, its use and distribution are strictly regulated due to its psychoactive properties and potential for abuse.

InChI:InChI=1/C9H7NO2/c1-2-10-7-4-9-8(3-6(1)7)11-5-12-9/h1-4,10H,5H2

Upstream product

• 15794-43-1 6,β-dinitro-3,4-methylenedioxystyrene 
• 80-73-9 1,3-dimethyl-2-imidazolidinone 
• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 
• 100587-74-4 5-(benzenesulfonyl)-[1,3]dioxolo[4,5-f]indole 
• 333441-11-5 N-Benzo[1,3]dioxol-5-yl-benzenesulfonamide 
• 32996-27-3 4,5-methylenedioxy-2-nitrotoluene 
• 124201-30-5 trans-1-(3,4-(Methylenedioxy)-6-nitrophenyl)-2-nitroethene 
• 86302-43-4 (tert-Butoxycarbonylmethylene)triphenylphosphorane 
• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 
• 107-21-1 ethylene glycol 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 63375-82-6 2-(6-bromo-benzo[1,3]dioxol-5-yl)-ethylamine 
• 32989-63-2 dimethyl[(E)-2-(6-nitro-2H-1,3-benzodioxol-5-yl)ethenyl]amine 
• 6315-90-8 4',5'-(methylenedioxy)-2-nitrocinnamic acid 

Downstream Products

• 98862-93-2 7-[1-(2,3-dimethoxy-phenyl)-2-nitro-ethyl]-5H-[1,3]dioxolo[4,5-f]indole 
• 100587-74-4 5-(benzenesulfonyl)-[1,3]dioxolo[4,5-f]indole 
• 113423-53-3 6,7,7-Tribromo-7H-[1,3]dioxolo[4,5-f]indole 
• 1034895-42-5 9-ING-41 
• 1292799-38-2 1-{[(5H-1,3-dioxolo[4,5-f]indol-7-yl)methyl]methylamino}-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol 
• 1292799-35-9 1-({[5-(tert-butoxycarbonyl)-1,3-dioxolo[4,5-f ]indol-7-yl]methyl}methylamino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol 
• 613679-41-7 5,6-methylenedioxy-1-(3',4',5'-trimethoxybenzoyl)indole 
• 100587-76-6 5,6-methylenedioxy-1-benzenesulfonylindole-2-sulfonyl chloride 
• 100587-77-7 5,6-methylenedioxy-1-benzenesulfonyl-2-sulfamoylindole 
• 88048-40-2 1-[(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-oxo-acetyl]-4-phenyl-piperazine 
• 4293-87-2 7-[2-(4-phenyl-piperazin-1-yl)-ethyl]-5H-[1,3]dioxolo[4,5-f]indole 
• 88048-41-3 1-(5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethane-1,2-dione 
• 6560-24-3 1-(4-Benzyl-piperazin-1-yl)-2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-ethane-1,2-dione 
• 88048-34-4 7-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-5H-[1,3]dioxolo[4,5-f]indole 

Relevant articles and documents

Synthesis of 5,6-carbonyldioxyindole, a melanogenic cyclic carbonate ester of 5,6-dihydroxyindole

5,6-Carbonyldioxyindole (4), a melanogenic derivative of 5,6-dihydroxyindole (1), was synthesized by a procedure starting with 3,4-methylenedioxycinnamic acid. Compound 4 is a stable crystalline solid which is readily hydrolyzed to 1, a key intermediate on the biosynthetic pathway from tyrosine to melanin.

INDOLE COMPOUND, OXIDATION DYE INTERMEDIATE, METHOD FOR PRODUCING INDOLE COMPOUND, AND METHOD FOR PRODUCING OXIDATION DYE-CONTAINING SOLUTION

PROBLEM TO BE SOLVED: To provide a novel indole compound to be a precursor of 5,6-dihydroxy indole, which has the nature of being easily oxidized and is, therefore, limited in its methods for production, a method for producing the indole compound, and a method for producing an oxidation dye-containing solution from the indole compound. SOLUTION: According to a method, a compound of formula (III) and boron trihalide are reacted to synthesize an indole compound, which is a boric acid ester of a 5,6-dihydroxy indole derivative. R1 and R2 independently represent H, a C1-C10 substituted/unsubstituted alkyl group, a C6-C10 substituted/unsubstituted aryl group, an oxygen-containing group, or a halogen atom; R3 is H, or a C1-C10 substituted/unsubstituted alkyl group; R4 and R5 independently represent H or a C1-C12 aliphatic group, or integrally represent a C1-C4 alkylene group. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS

This invention relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating bacterial infections. This invention relates more particularly to compounds and pharmaceutical compositions thereof, methods of inhibiting H2S-producing enzymes with the compounds, and methods of treating bacterial infections with the compounds.

SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H-[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE

The present disclosure relates to solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl) pyrrole-2,5-dione, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof in treating disease.