1035263-31-0Relevant articles and documents
OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE
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Page/Page column 171, (2019/06/05)
Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.
Stereoretentive Intramolecular Glycosyl Cross-Coupling: Development, Scope, and Kinetic Isotope Effect Study
Yi, Duk,Zhu, Feng,Walczak, Maciej A.
supporting information, p. 4627 - 4631 (2018/08/07)
A series of cyclic C-glycosides were synthesized using the palladium-catalyzed stereoretentive intramolecular glycosylation of aryl iodides by employing a bulky phosphine ligand. A variety of functional groups are tolerated in the reaction, and enantioenr
A concise synthesis of chiral indanes as α1A adrenoceptor partial agonists
Roberts, Lee R.,Corbett, Matthew S.,Fussell, Steven J.,Hitzel, Laure,Jessiman, Alan S.,Mason, Helen J.,Osborne, Rachel,Ralph, Michael J.,Stennett, Adam S.D.,Wheeler, Simon,Storer, R. Ian
supporting information, p. 6546 - 6550 (2015/11/09)
The synthesis of a series of chiral indanes with reported α1A partial agonist activity is outlined, applying a rhodium catalysed cyclisation for template construction. This method was extended to the asymmetric synthesis of lead compound PF-037
DIFLUOROMETHYLENE COMPOUND
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Paragraph 0404; 0405; 0897; 0898, (2015/06/16)
The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.
Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists
Roberts, Lee R.,Bryans, Justin,Conlon, Kelly,McMurray, Gordon,Stobie, Alan,Whitlock, Gavin A.
scheme or table, p. 6437 - 6440 (2009/10/01)
A novel series of central nervous system (CNS) penetrant indane 2-imidazoles have been identified as potent, partial agonists of the α1A adrenergic receptor, having good selectivity over the α1B, α1D and α2 sub-
Synthesis and Structure of 1,7-Dichlorodibenzoheptalene-4,10-dione, a Saddle-Shaped Polycyclic Aromatic Compound
Pascal, Robert A.,Ho, Douglas M.
, p. 13 - 16 (2007/10/02)
We describe the synthesis and X-ray crystal structure of the title compound, which is the first fully unsaturated derivative of dibenzoheptalene to be prepared.The X-ray structure reveals a saddle-shaped molecule possessing approximate C2/sub