- Synthesis and antitumor activities of platinum complexes of unsymmetrical alicyclic diamines as carrier ligands
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The synthesis and biological activities of the platinum complexes of 2-aminomethylaziridine, 2-aminomethylazetidine, 2-aminomethylpyrrolidine, and 2-aminomethylpiperidine as carrier ligands are described. The platinum complexes of 2-aminomethylazetidine and 2-aminomethylpyrrolidine are significantly effective against murine tumors. In particular, 2-aminomethylazetidine (1,1-cyclobutanedi-carboxyplato)platinum II (13) and 2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)platinum II (16) exhibited potent antitumor activity and were soluble in water, and their antitumor activities against Colon 26 carcinoma (sc-ip system) were superior to CBDCA and comparable to CDDP.
- Morikawa,Honda,Endoh,Matsumoto,Akamatsu,Mitsui,Koizumi
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- 7-(2-Aminomethyl-1-azetidinyl)-4-oxoquinoline-3-carboxylic acids as potent antibacterial agents: Design, synthesis, and antibacterial activity
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2-Aminomethyl-1-azetidinyl, -1-pyrrolidinyl, and -1-piperidinyl groups were designed as novel C-7 substituents for potential antibacterial quinolone agents. Of the three substituents, the 2-aminomethyl-1-azetidinyl group (compound 12a) was found to be the
- Fujita, Masahiro,Chiba, Katsumi,Tominaga, Yukio,Hino, Katsuhiko
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p. 787 - 796
(2007/10/03)
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