103554-58-1Relevant articles and documents
New acridone-4-carboxylic acid derivatives as potential inhibitors of Hepatitis C virus infection
Stankiewicz-Drogon, Anna,Palchykovska, Larisa G.,Kostina, Valentina G.,Alexeeva, Inna V.,Shved, Anatoly D.,Boguszewska-Chachulska, Anna M.
experimental part, p. 8846 - 8852 (2009/04/11)
A new class of compounds-acridone derivatives-was tested using the direct fluorometric helicase activity assay to determine the inhibitory properties of the derivatives towards the NS3 helicase of Hepatitis C virus (HCV). The compounds were also tested as
Synthesis and evaluation of novel pyrimido-acridone, -phenoxadine, and -carbazole as topoisomerase II inhibitors
Kamata, Junichi,Okada, Toshimi,Kotake, Yoshihiko,Niijima, Jun,Nakamura, Katsuji,Uenaka, Toshimitsu,Yamaguchi, Atsumi,Tsukahara, Kappei,Nagasu, Takeshi,Koyanagi, Nozomu,Kitoh, Kyosuke,Yoshimatsu, Kentaro,Yoshino, Hiroshi,Sugumi, Hiroyuki
, p. 1071 - 1081 (2007/10/03)
As part of a series of studies to discover new topoisomerase II inhibitors, novel pyrimidoacridones, pyrimidophenoxadines, and pyrimidocarbazoles were synthesized, and in vitro and in vivo antitumor activities and DNA-protein and/or DNA-topoisomerase II c
Pyrimidoacridine derivatives as potential antitumor agents
Antonini,Cola,Martelli,Cholody,Konopa
, p. 1035 - 1046 (2007/10/02)
A series of some N-alkylaminoalkyl derivatives of pyrimido[5,6,1-d,e]acridine-1,3,7-trione (3) was synthesized as new potential antitumor drugs, starting from the suitable 9,10-dihydro-9-oxo-4-acridinecarboxamides and using phosgene as cyclizing agent. 1-(9,10-dihydro-9-oxo-4-acridinecarbonyl)-3-alkyl-2-imidazolidones were also obtained as side products. The final products 3 and some carboxamides were tested 'in vitro' against L 1210 leukemia and 'in vivo' against P388 leukemia. Of the tested compounds, one is active 'in vivo', another shows significant cytotoxic activity 'in vitro', but is inactive or toxic 'in vivo'.
