cas 103628-48-4, Sumatriptan succinate | Articles data

Articles about 103628-48-4Total 7 be found

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Isotope-Edited Infrared Spectroscopy for Efficient Discrimination between Pharmaceutical Salts and Cocrystals
Isotope-edited infrared spectroscopy using carboxylic acids selectively labeled with 13C is proposed herein for the efficient discrimination of pharmaceutical salts and cocrystals, whereby proton-transfer probe vibrations are highlighted by isotope shifts. This new technique can accurately discriminate even a confusing salt from a cocrystal for the traditional method, highlighting the diagnostic peaks. In addition, the established technique also provided the OH in-plane bending vibrations corresponding to intermolecular hydrogen bonding at the carbonyl oxygens of the cocrystals. The technique will accelerate the discrimination, which is a critical process in cocrystal development.
Iwata, Kentaro,Karashima, Masatoshi,Ikeda, Yukihiro
p. 2350 - 2358
(2017)
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PROCESS FOR PREPARING 3-(2-(DIMETHYLAMINO)ETHYL)-N- METHYL-1H-INDOLE-5-METHANESULFONAMIDE AND PRODUCT THEREOF
The present invention relates to an improved process for the preparation of 3-(2- (dimethylamino) ethyl)-N-methyl- 1 H-indole-5-methanesulfonamide (sumatriptan) acid addition salt and the base having enhanced yield and purity. Further the present invention also provides a novel crystalline sumatriptan base.
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Page/Page column 10-11; 12; 13

(2009/04/25)

SUMATRIPTAN CRYSTALLINE FORMS, PHARMACEUTICAL COMPOSITIONS AND METHODS
The invention provides novel soluble sumatriptan crystalline forms that include polymorphs, salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these sumatriptan crystalline forms. Methods of using such compositions for the treatment or prevention of migraine headaches and related neurological disorders are also provided.
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Page 35-36

(2008/06/13)

Amorphous form of 3-[2-(dimethylamino) ethyl]-N-methyl-1H-indole-5-methane sulfonamide succinate (sumatriptan succinate)
The present invention relates to an amorphous form of Sumatriptan succinate of Formula (1). The present invention also relates to process for the preparation of an amorphous form of Sumatriptan succinate. The process for the preparation of an amorphous form of Sumatriptan succinate comprises refluxing an aqueous mixture of Sumatriptan or its succinate salt in alcoholic solvents such as methanol or nitrile solvents such as acetonitrile followed by evaporation of the solvent from the filtrate. The resulting residue is triturated with water immiscible aromatic or aliphatic hydrocarbon solvents such as cyclohexane to afford an amorphous form of Sumatriptan succinate.
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Page 2-3

(2008/06/13)

NOVEL CRYSTALLINE FORMS OF SUMATRIPTAN SUCCINATE
The present invention relates to novel crystalline forms of sumatriptan succinate, to processes for their preparation and to pharmaceutical compositions containing them.
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Page 3-4

(2008/06/13)

A NOVEL PROCESS FOR PREPARATION OF INDOLE DERIVATIVES
A novel process of preparation of a compound of 3-(2-Dimethylamino)-N-methyl-lH-indole-5-methane sulfonamide, which comprises of a reaction 4-hydrazino-N-methyl benzene methane sulfonamide with 4-dimethyl amino butyraldehyde diethyl acetal in a chlorinated solvent in the presence of ethyl poly phosphate and conversion of the crude product to a product of 3-(2-Dimethylamino)-N-methyl-lH-indole-5-methane sulfonamide succinate of extra high purity and colour.
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Page 10-17

(2010/02/09)

3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide and the Succinate Thereof
A process for the preparation of highly pure Sumatriptan is described. A process for the preparation of novel crystalline Form I and crystalline Form II of Sumatriptan succinate is described. Sumatriptan is used for alleviating the pain of migraine headaches.
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Page 17

(2008/06/13)

Chemical Properties

Appearance/Colour :white powder
Melting Point: 165-166°C
Boiling Point: 497.7 °C at 760 mmHg
Flash Point:254.8 °C
Density: 1.243 g/cm³
Solubility:H2O: >20mg/mL
Storage Temp.:Store at +4°C
Vapor Pressure: 1.24E-17mmHg at 25°C
Merck: 14,8997
PSA: 148.18000
LogP: 2.72870

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103628-48-4

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Chemical Properties

Appearance/Colour :white powder

Melting Point: 165-166°C

Boiling Point: 497.7 °C at 760 mmHg

Flash Point:254.8 °C

Density: 1.243 g/cm³

Solubility:H2O: >20mg/mL

Storage Temp.:Store at +4°C

Vapor Pressure: 1.24E-17mmHg at 25°C

Merck: 14,8997

PSA: 148.18000

LogP: 2.72870

Global suppliers and manufacturers of 103628-48-4total 163 suppliers on LookChem

Article Database

103628-48-4

Articles about 103628-48-4Total 7 be found

More Articles about upstream products of 103628-48-4

More Articles about downstream products of 103628-48-4

Chemical Properties

Appearance/Colour :white powder

Melting Point: 165-166°C

Boiling Point: 497.7 °C at 760 mmHg

Flash Point:254.8 °C

Density: 1.243 g/cm3

Solubility:H2O: >20mg/mL

Storage Temp.:Store at +4°C

Vapor Pressure: 1.24E-17mmHg at 25°C

Merck: 14,8997

PSA: 148.18000

LogP: 2.72870

Global suppliers and manufacturers of 103628-48-4total 163 suppliers on LookChem

Density: 1.243 g/cm³