INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-PHENYL DERIVATIVES
Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
-
Page/Page column 46-47; 53
(2009/10/30)
Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the sonogashira reaction
(Chemical Equation Presented) The divergent synthesis of a 21-member library composed of 2-aminoimidazole compounds for evaluation as novel antibiofilm molecules is presented. The Sonogashira reaction was employed with three regioisomeric aryl iodides and 11 different alkynes to generate variously substituted diverse ring systems. Good to excellent yields (80-97%) for the reaction were obtained, and the products provide adequate handles for further manipulation into more advanced analogues.
Richards, Justin J.,Melander, Christian
p. 5191 - 5193
(2008/12/20)
More Articles about upstream products of 1037183-80-4