113258-84-7

Basic information

• Product Name: Ethanone, 2-broMo-1-(2-iodophenyl)-
• Synonyms: Ethanone, 2-broMo-1-(2-iodophenyl)-
• CAS NO: 113258-84-7
• Molecular Formula: C₈H₆BrIO
• Molecular Weight: 324.94111
• Mol File: 113258-84-7.mol

Chemical Properties

• Boiling Point: 162-164 °C(Press: 6 Torr)
• Appearance: /
• Density: 2.080±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 2-broMo-1-(2-iodophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-broMo-1-(2-iodophenyl)-(113258-84-7)
• EPA Substance Registry System: Ethanone, 2-broMo-1-(2-iodophenyl)-(113258-84-7)

Safety Data

• Hazardous Substances Data: 113258-84-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 2-bromo-1-(2-iodophenyl)is used as a chemical intermediate for the synthesis of various drugs. Its unique structure allows it to be a key component in the development of new medications, contributing to the advancement of pharmaceutical research and drug discovery.
Used in Agrochemical Industry:
In the agrochemical sector, Ethanone, 2-bromo-1-(2-iodophenyl)is employed as an intermediate in the production of agrochemicals. Its role in the synthesis of these compounds helps in the development of effective pesticides, herbicides, and other agricultural products that are essential for maintaining crop health and productivity.
Used in Organic Chemical Reactions:
Ethanone, 2-bromo-1-(2-iodophenyl)is utilized as a reagent in various organic chemical reactions. Its presence in these reactions can facilitate the formation of desired products, making it a valuable tool for chemists and researchers working in the field of organic chemistry.

Upstream product

• 2142-70-3 2-iodoacetophenone 
• 18282-40-1 1-ethyl-2-iodobenzene 
• 551-93-9 2-aminoacetophenone 
• 88-67-5 2-Iodobenzoic acid 
• 186581-53-3 diazomethane 
• 609-67-6 2-Iodobenzoyl chloride 

Downstream Products

• 1037183-80-4 2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester 
• 452962-75-3 1-(2-iodophenyl)-2-phenoxyethanone 
• 452962-66-2 3-(2-iodophenyl)benzofuran 

Relevant articles and documents

N-Heterocyclic Iod(az)olium Salts – Potent Halogen-Bond Donors in Organocatalysis

This article describes the application of N-heterocyclic iod(az)olium salts (NHISs) as highly reactive organocatalysts. A variety of mono- and dicationic NHISs are described and utilized as potent XB-donors in halogen-bond catalysis. They were benchmarked in seven diverse test reactions in which the activation of carbon- and metal-chloride bonds as well as carbonyl and nitro groups was achieved. N-methylated dicationic NHISs rendered the highest reactivity in all investigated catalytic applications with reactivities even higher than all previously described monodentate XB-donors based on iodine(I) and (III) and the strong Lewis acid BF3.

FUSED IMIDAZOLE DERIVATIVES AS IDO/TDO INHIBITORS

The present application relates to compounds and methods for the modulation (e.g., inhibition) of the enzyme indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase (IDO/TDO), and methods of treating diseases and disorders in which IDO/TDO plays a r

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH)

Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function. In this context, we established and validated a straightforward enzymatic assay suitable for high-throughput screening and we identified inhibitors with similar chemical scaffolds. Through a convergent pharmacophore approach, we synthesized α-ketothioamides that exhibit interesting in vitro PHGDH inhibition and encouraging cellular results. These novel probes may be used to understand the emerging biology of this metabolic target.

Direct Transformation of Ethylarenes into Primary Aromatic Amides with N -Bromosuccinimide and I2-Aqueous NH3

A variety of ethylarenes were converted into the corresponding primary aromatic amides in good yields via treatment with N-bromosuccinimide in the presence of a catalytic amount of 2,2′-azobis(isobutyronitrile) in a mixture of ethyl acetate and water, acetonitrile and water, or chloroform and water, followed by reaction with molecular iodine and aq NH3 in one pot. It was found that aryl α-bromomethyl ketones and/or aryl methyl ketones were formed at the first reaction step and their iodoform-type reaction occurred at the second reaction step to provide primary aromatic amides. The present reaction is a useful and practical transition-metal-free method for the preparation of primary aromatic amides from ethylarenes. (Chemical Equation Presented).

FUSED-RING COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES THEREOF

This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.

THIAZOLE DERIVATIVES FOR THE TREATMENT OF ANIMAL TRYPANOSOMIASIS

The present invention relates to a novel class of compounds of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, X and Y are as defined herein, to their use in human and veterinary medicine, and in the treatment of animal trypanosomiasis in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

Flexible routes to thiophenes

Three convergent routes to thiophenes are described, hinging on the radical addition of α-xanthyl ketones to ethyl vinyl sulfide or to vinyl pivalate. The latter route ultimately proved to be the most versatile and efficient (61-94%).

Base-catalyzed synthesis of substituted indazoles under mild, transition-metal-free conditions

Back to basics: A transition-metal-free method developed for the synthesis of indazoles involves an inexpensive catalytic system composed of a diamine and K2CO3. Various (Z)-2-bromoacetophenone tosylhydrazones were converted into indazoles at room temperature in excellent yields (see example; Ts=p-toluenesulfonyl). The yield was improved by photoisomerization with UV light when E/Z isomeric mixtures of the starting material were used. Copyright

INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-PHENYL DERIVATIVES

Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.

Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the sonogashira reaction

(Chemical Equation Presented) The divergent synthesis of a 21-member library composed of 2-aminoimidazole compounds for evaluation as novel antibiofilm molecules is presented. The Sonogashira reaction was employed with three regioisomeric aryl iodides and 11 different alkynes to generate variously substituted diverse ring systems. Good to excellent yields (80-97%) for the reaction were obtained, and the products provide adequate handles for further manipulation into more advanced analogues.