103793-22-2Relevant articles and documents
Method for treating fibrotic diseases or other indications with imidazolium agents
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, (2008/06/13)
Provided is a method of treating or ameliorating an indication of the invention in an animal, including a human, by administering an effective amount of a compound of the formula I: wherein R1, R2, M, X and Z are as described supra. Also provided are certain imidazolium compounds and pharmaceutical compositions containing the imidazolium compounds.
Method for treating fibrotic diseases or other indications IC
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, (2011/07/06)
Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:
Substituted imidazolium salts and their use for the inhibition of protein ageing.
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Page 9, (2008/06/13)
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein ageing). Accordingly, compositions are disclosed which comprise substituted imidazolium compounds capable of inhibiting the formatio
Oral Hypoglycemic Agents. Discovery and Structure-Activity Relationships of Phenacylimidazolium Halides
Dominianni, Samuel J.,Yen, Terence T.
, p. 2301 - 2306 (2007/10/02)
Blood glucose levels in viable, yellow, obese, diabetic mice are reduced following oral administration of phenacylimidazolium halides.Compounds 2 and 3 produced reductions of ca. 40percent 2 h after doses of 100 mg/kg po.Since these mice do not respond to sulfonylureas, the glucose-lowering activity of phenacylimidazolium salts in this model suggests a mechanism other than that of stimulating insulin secretion.Only phenacylimidazolium halides with electron-donating groups were active; other azolium salts or variations in the phenacyl portion (alterations in the keto function; chain lengthening or extensive branching) produced inactive compounds.
Imidazolium hypoglycemic agents
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, (2008/06/13)
Imidazolium salts are effective in lowering blood glucose levels in mammals following administration.