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616-47-7 Usage

Chemical Properties

1-Methylimidazole or N-methylimidazole is an aromatic heterocyclic organic compound with the formula CH3C3H3N2. It is a colorless to yellow liquid, with an amine-like odor. It is miscible with water. N-methylimidazole is an important raw material for the synthesis of pharmaceutical intermediates, used in the preparation of losartan, nizofenone, 1-Methyl-1H-imidazole-5-carbonyl chloride hydrochloride and naphazoline hydrochloride, etc. It is also used as a specialty solvent, a base, and as a precursor to some ionic liquids.


1-Methylimidazole is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate. It is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.


ChEBI: 1-methyl-1H-imidazole is a 1H-imidazole having a methyl substituent at the N-1 position. It is a metabolite of 1-methyl-2-thioimidazole (methimazole). It inhibits bone resorption.


1-Methylimidazole is prepared mainly by two routes industrially. The main one is acid-catalysed methylation of imidazole by methanol. The second method involves the Radziszewski reaction from glyoxal, formaldehyde, and a mixture of ammonia and methylamine. (CHO)2 + CH2O + CH3NH2 + NH3 → H2C2N(NCH3)CH + 3 H2O The compound can be synthesized on a laboratory scale by methylation of imidazole at the pyridine-like nitrogen and subsequent deprotonation. Similarly, 1-methylimidazole may be synthesized by first deprotonating imidazole to form a sodium salt followed by methylation. H2C2N(NH)CH + CH3I → [H2C2(NH)(NCH3)CH]I [H2C2(NH)(NCH3)CH]I + NaOH → H2C2N(NCH3)CH + H2O + NaI

General Description

This product has been enhanced for catalysis. 1-Methylimidazole is a derivative of imidazole that is utilized in the manufacture of such classes of items as pharmaceuticals, pesticides, ion-exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors. It is also used as a catalyst for manufacturing polyurethanes and a curing agent for epoxy resins.

Flammability and Explosibility


Purification Methods

Dry it with sodium metal and then distil it. Store it at 0o under dry argon. The picrate has m 159.5-160.5o (from H2O). [Beilstein 23 III/IV 568.]

Check Digit Verification of cas no

The CAS Registry Mumber 616-47-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 616-47:
67 % 10 = 7
So 616-47-7 is a valid CAS Registry Number.

616-47-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A12575)  1-Methylimidazole, 99%   

  • 616-47-7

  • 100g

  • 240.0CNY

  • Detail
  • Alfa Aesar

  • (A12575)  1-Methylimidazole, 99%   

  • 616-47-7

  • 500g

  • 943.0CNY

  • Detail
  • Alfa Aesar

  • (A12575)  1-Methylimidazole, 99%   

  • 616-47-7

  • 2kg

  • 2712.0CNY

  • Detail
  • Aldrich

  • (M50834)  1-Methylimidazole  ReagentPlus®, 99%

  • 616-47-7

  • M50834-100G

  • 279.63CNY

  • Detail
  • Aldrich

  • (M50834)  1-Methylimidazole  ReagentPlus®, 99%

  • 616-47-7

  • M50834-500G

  • 1,099.80CNY

  • Detail
  • Vetec

  • (V900088)  1-Methylimidazole  Vetec reagent grade, 98%

  • 616-47-7

  • V900088-100ML

  • 168.48CNY

  • Detail
  • Sigma-Aldrich

  • (336092)  1-Methylimidazole  ≥99%, purified by redistillation

  • 616-47-7

  • 336092-100ML

  • 1,165.32CNY

  • Detail
  • Sigma-Aldrich

  • (336092)  1-Methylimidazole  ≥99%, purified by redistillation

  • 616-47-7

  • 336092-1L

  • 3,893.76CNY

  • Detail
  • Sigma-Aldrich

  • (336092)  1-Methylimidazole  ≥99%, purified by redistillation

  • 616-47-7

  • 336092-2L

  • 6,025.50CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017


1.1 GHS Product identifier

Product name 1-methyl-1H-imidazole

1.2 Other means of identification

Product number -
Other names N-Methylhistamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. CBI,Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:616-47-7 SDS

616-47-7Relevant articles and documents

Selective N-Alkylation of Imidazole with Alcohols over Calcined Layered Double Hydroxides

Santhanalakshmi, Jayadevan,Raja, Thirumalaiswamy

, p. 2829 - 2831 (1997)

Vapor-phase N-alkylation syntheses of imidazole were carried out with MeOH and EtOH over a series of calcined MgII-AlIII layered double hydroxides (LDHs) selectively produced in high yields of N-methyl (70%) and N-ethyl (63%) imidazoles only on the 3 : 1 atomic ratio of MgII-AlIII calcined LDH. Attempts on C-alkylation and dialkylation reactions over the same catalysts proved to be unsuccessful.

Reactivity of Ionic Liquids: Reductive Effect of [C4C1im]BF4 to Form Particles of Red Amorphous Selenium and Bi2Se3 from Oxide Precursors

Knorr, Monika,Schmidt, Peer

, p. 125 - 140 (2020/12/17)

Temperature-induced change in reactivity of the frequently used ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([C4C1im]BF4) is presented as a prerequisite for the rational screening of reaction courses in material synthesis. [C4C1im]BF4 becomes active with oxidic precursor compounds in reduction reaction at ?≥200 °C, even without the addition of an external reducing agent. The reaction mechanism of forming red amorphous selenium from SeO2 is investigated as a model system and can be described similarly to the Riley oxidation. The reactive species but-1-ene, which is formed during the decomposition of [C4C1im]BF4, reacts with SeO2 and form but-3-en-2-one, water, and selenium. Elucidation of the mechanism was achieved by thermoanalytical investigations. The monotropic phase transition of selenium was analyzed by the differential scanning calorimetry. Beyond, the suitability of the single source oxide precursor Bi2Se3O9 for the synthesis of Bi2Se3 particles was confirmed. Identification, characterization of formed solids succeeded by using light microscopy, XRD, SEM, and EDX.

N-Alkylation of Imidazoles with Dialkyl and Alkylene Carbonates


, p. 2079 - 2086 (2021/02/09)

Abstract: The reactions of imidazoles with a series of dialkyl and alkylene carbonatesafforded the corresponding N-alkyl- andN-(hydroxyalkyl)imidazoles with highyields. The reactivity of dialkyl carbonates decreases in the series dimethyl> diethyl > dibutyl carbonate. Ethylene carbonate is a more efficientalkylating agent than trimethylene carbonate. The mechanisms of alkylation ofimidazole with dimethyl carbonate and ethylene carbonate were studied by DFTquantum chemical calculations at the B3LYP/6-311++G(d,p) level of theory.

Molecular tunability of surface-functionalized metal nanocrystals for selective electrochemical CO2 reduction

Pankhurst, James R.,Guntern, Yannick T.,Mensi, Mounir,Buonsanti, Raffaella

, p. 10356 - 10365 (2019/11/20)

Organic ligands are used in homogeneous catalysis to tune the metal center reactivity; in contrast, clean surfaces are usually preferred in heterogeneous catalysis. Herein, we demonstrate the potential of a molecular chemistry approach to develop efficient and selective heterogeneous catalysts in the electrochemical CO2 reduction reaction (CO2RR). We have tailor-made imidazolium ligands to promote the CO2RR at the surface of hybrid organic/inorganic electrode materials. We used silver nanocrystals for the inorganic component to obtain fundamental insights into the delicate tuning of the surface chemistry offered by these ligands. We reveal that modifying the electronic properties of the metal surface with anchor groups along with the solid/liquid interface with tail groups is crucial in obtaining selectivities (above 90% FE for CO), which are higher than the non-functionalized Ag nanocrystals. We also show that there is a unique dependency of the CO2RR selectivity on the length of the hydrocarbon tail of these ligands, offering a new way to tune the interactions between the metal surface with the electrolyte and reactants.

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