Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design
Ricin toxin A subunit (RTA) is the catalytic subunit of ricin, which depurinates an adenine from the sarcin/ricin loop in eukaryotic ribosomes. There are no approved inhibitors against ricin. We used a new strategy to disrupt RTA-ribosome interactions by
Augeri, David,Cao, Bin,Harijan, Rajesh K.,Kahn, Jennifer N.,Li, Xiao-Ping,Pierce, Michael,Roberge, Jacques Y.,Tsymbal, Anastasiia M.,Tumer, Nilgun E.
p. 15334 - 15348
(2021/11/01)
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