10389-73-8Relevant articles and documents
Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination
Du, Yi-Dan,Chen, Bi-Hong,Shu, Wei
supporting information, p. 9875 - 9880 (2021/03/29)
Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.
ONE STEP PROCESS FOR THE PREPARATION OF PHENYL ETHYL AMINE DERIVATIVES
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Page/Page column 6-7, (2021/06/11)
The present invention relates to a novel process for the preparation of phenyl ethyl amine derivatives by reacting a phenyl ethyl hydroxy compound with hydrogen cyanide followed by in situ hydrolysis.
Novel synthesis method of 2-methyl-1-substituted phenyl-2-propylamine compounds
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Paragraph 0021; 0027- 0037; 0046; 0052; 0053, (2019/05/08)
The invention discloses a novel synthesis method of 2-methyl-1-substituted phenyl-2-propylamine compounds, and belongs to the field of material synthesis. The method comprises steps as follows: substituted benzyl halide is taken as a raw material and subj
Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
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, (2008/06/13)
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.