Clortermine

Base Information

• Chemical Name: Clortermine
• CAS No.: 10389-73-8
• Molecular Formula: C10H14 Cl N
• Molecular Weight: 183.681
• Hs Code.: 2921499090
• UNII: 4FA88HM3IX
• DSSTox Substance ID: DTXSID0022850
• Nikkaji Number: J10.469H
• Wikipedia: Clortermine
• Wikidata: Q5135153
• NCI Thesaurus Code: C65344
• Metabolomics Workbench ID: 143589
• ChEMBL ID: CHEMBL1697833
• Mol file: 10389-73-8.mol

Synonyms:CLORTERMINE;10389-73-8;Clortermine [INN];1-(2-chlorophenyl)-2-methylpropan-2-amine;1-(o-Chlorophenyl)-2-methyl-2-aminopropane;Clortermina;Clorterminum;Clorterminum [INN-Latin];Clortermina [INN-Spanish];o-Chlorophentermine;HSDB 3306;UNII-4FA88HM3IX;chlortermine;4FA88HM3IX;o-Chloro-alpha,alpha-dimethylphenethylamine;1-(o-Chlorophenyl)-2-methyl-2-propylamine;DTXSID0022850;2-Chloro-alpha,alpha-dimethylbenzeneethanamine;Phenethylamine, o-chloro-alpha,alpha-dimethyl-;Benzeneethanamine, 2-chloro-alpha,alpha-dimethyl-;Benzeneethanamine, 2-chloro-.alpha.,.alpha.-dimethyl-;DEA No. 1647;1-(2-Chlorophenyl)-2-methyl-2-propanamine;o-Chloro-.alpha.,.alpha.-dimethylphenethylamine;o-Chloro-.alpha.,.alpha.-dimethylphenethylamine hydrochloride;NSC104068;.alpha.,.alpha.-dimethyl-o-chlorophenethylamine hydrochloride;Phenethylamine, o-chloro-.alpha.,.alpha.-dimethyl-, hydrochloride;CLORTERMINE [MI];CLORTERMINE [HSDB];NCIOpen2_001902;CLORTERMINE [WHO-DD];SCHEMBL164137;DTXCID302850;CHEMBL1697833;CHEBI:134826;Tox21_113863;AB07476;DB01527;NCGC00253747-01;alpha,alpha-dimethyl-2-chlorophenethylamine;2-(2-Chlorophenyl)-1,1-dimethylethylamine;CAS-10389-73-8;LS-171895;1-(2-chlorophenyl)-2-methyl-propan-2-amine;Phenethylamine, o-chloro-.alpha.,.alpha.-dimethyl-;Q5135153

Chemical Property of Clortermine

Chemical Property:

• Vapor Pressure: 0.016mmHg at 25°C
• Boiling Point: 255.8°Cat760mmHg
• PKA: 9.60±0.25(Predicted)
• Flash Point: 127°C
• PSA: 26.02000
• Density: 1.074g/cm³
• LogP: 3.32010
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 183.0814771
• Heavy Atom Count: 12
• Complexity: 145

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-CHLOROPHENYL)-2-METHYLPROPAN-2-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CC1=CC=CC=C1Cl)N
• Uses: Anorexic.
• Therapeutic Function: Antiobesity

Technology Process of Clortermine

There total 7 articles about Clortermine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-chloro-β,β-dimethylstyrene (93738-94-4) → α,α-dimethyl-2-chlorophenethylamine (10389-73-8)

Guidance literature:

With 10-phenyl-9-(2,4,6-trimethylphenyl)acridinium tetrafluoroborate; ammonium carbonate; 2-amino-benzenethiol; In dichloromethane; chlorobenzene; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/anie.202016679

Reference yield: 51.0%

→ α,α-dimethyl-2-chlorophenethylamine (10389-73-8)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene;

With hydrogenchloride; acetic acid; In water;

Reference yield:

1-(2-chlorophenyl)-2-methyl-2-nitropropane (79257-74-2) → N-(α,α-Dimethyl-2-chlorophenethyl)-2-quinoxalinecarboxamide (226878-22-4) + α,α-dimethyl-2-chlorophenethylamine (10389-73-8)

Guidance literature:

aluminum nickel; In ethanol; water;

upstream raw materials:

1-amino-2-(2-amino-2-methylpropyl)benzene

N-Formyl-1.1-dimethyl-2-<2-chlor-phenyl>-aethylamin

o-chloro-α,α-dimethylphenethyl alcohol

1-chloro-2-(chloromethyl)benzene

Downstream raw materials:

N-(α,α-Dimethyl-2-chlorophenethyl)-2-quinoxalinecarboxamide