103914-53-0

Basic information

• Product Name: 2-(4-bromophenyl)quinoline-4-carbonyl chloride
• Synonyms: 2-(4-bromophenyl)quinoline-4-carbonyl chloride;4-quinolinecarbonyl chloride, 2-(4-bromophenyl)-;2-(4-bromophenyl)-4-quinolinecarbonyl chloride
• CAS NO: 103914-53-0
• Molecular Formula: C₁₆H₉BrClNO
• Molecular Weight: 346.60576
• Mol File: 103914-53-0.mol

Chemical Properties

• Boiling Point: 480.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.542±0.06 g/cm3(Predicted)
• PKA: 1.21±0.33(Predicted)
• CAS DataBase Reference: 2-(4-bromophenyl)quinoline-4-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)quinoline-4-carbonyl chloride(103914-53-0)
• EPA Substance Registry System: 2-(4-bromophenyl)quinoline-4-carbonyl chloride(103914-53-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 103914-53-0(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound with a quinoline ring and a 4-bromophenyl group attached

Derivative

Carbonyl chloride derivative of 2-(4-bromophenyl)quinoline

Usage

Organic synthesis reagent for the preparation of various quinoline-based compounds

Reactivity

Reactive compound that can undergo reactions with nucleophiles to form new carbon-carbon and carbon-heteroatom bonds

Potential applications

Medicinal chemistry and pharmaceutical research due to the structural characteristics and biological activities of quinoline derivatives

Upstream product

• 99-90-1 para-bromoacetophenone 
• 91-56-5 indole-2,3-dione 
• 103914-52-9 2-(4'-bromophenyl)quinoline-4-carboxylic acid 

Downstream Products

• 103914-54-1 2-(4-bromophenyl)-4-chloroquinoline 
• 350997-62-5 methyl 2-(4'-bromophenyl)-quinoline-4-carboxylate 

Relevant articles and documents

Hypoboric acid derivative based on 2-(4-dyhydroxy borane)pheoylquinoline-4-carboxylic acid and preparation method and application thereof

The invention discloses a hypoboric acid derivative based on 2-(4-dyhydroxy borane)pheoylquinoline-4-carboxylic acid and a preparation method thereof. The hypoboric acid derivative is used for preparing catecholamine and carbohydrate fluorescent probes. T

Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay

Cyclophilin A (CypA) is a member of cyclophilins, a family of the highly homologous peptidyl prolyl cis-trans isomerases (PPIases), which can bind to cyclosporin A (CsA). CypA plays critical roles in various biological processes, including protein folding, assembly, transportation, regulation of neuron growth, and HIV replication. The discovery of CypA inhibitor is now of a great special interest in the treatment of immunological disorders. In this study, a series of novel small molecular CypA inhibitors have been discovered by using structure-based virtual screening in conjunction with chemical synthesis and bioassay. The SPECS_1 database containing 85,000 small molecular compounds was searched by virtual screening against the crystal structure of human CypA. After SPR-based binding affinity assay, 15 compounds were found to show binding affinities to CypA at submicro-molar or micro-molar level (compounds 1-15). Seven compounds were selected as the starting point for the further structure modification in considering binding activity, synthesis difficulty, and structure similarity. We thus synthesized 40 new small molecular compounds (1-6, 15, 16a-q, 17a-d, and 18a-l), and four of which (compounds 16b, 16h, 16k, and 18g) showed high CypA PPIase inhibition activities with IC50s of 2.5-6.2 μM. Pharmacological assay indicated that these four compounds demonstrated somewhat inhibition activities against the proliferation of spleen cells.

4-Piperidino-2-phenylquinolines

Disclosed are compounds of the formula STR1 wherein: R1 and R2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R3 and R4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R3 and R4 cannot both be hydrogen. These compounds are useful as anticonvulsant or anxiolytic agents.