- Preparation method N -methoxycarbonyl -3 -trifluoromethylpyridine -2 - sulfanilamide
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The invention relates to a preparation method of N - methoxycarbonyl -3 -trifluoromethylpyridine -2 - sulfanilamide, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: preparing 3 -trifluoromethylpyridine -2 - sulfonyl chloride containing urea and acid. Methyl carbamate is obtained as a raw material, and then 3 - trifluoromethylpyridine -2 - sulfonyl chloride and methyl carbamate are used as raw materials to obtain N - methoxycarbonyl -3 - trifluoromethylpyridine -2 - sulfanilamide. The preparation method disclosed by the invention has the advantages of few reaction steps, simple reaction conditions and cheap and accessible raw materials.
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Paragraph 0030; 0033-0034
(2021/11/19)
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- Flazasulfuron: Alcoholysis, Chemical Hydrolysis, and Degradation on Various Minerals
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The herbicide flazasulfuron undergoes rapid alcoholysis. High yields of the corresponding carbamate and aminopyrimidine are obtained after the alcoholysis process (methanol or ethanol) at 30 °C in the course of which the concomitant rearrangement reaction remains minor. Hydrolysis (pH ranging from 5 to 11) of flazasulfuron at 30 °C principally involves the rearrangement into urea after elimination of S02 and can lead, in a small proportion, to both aminopyrimidine and pyridinesulfonamide. First-order kinetics correctly describes the rates of alcoholysis and hydrolysis. The sulfonylurea-bridge contraction and final transformation into the correspondent amine were evaluated with a first-order kinetics hypothesis. Transformations in amine and urea in aqueous medium are pH dependent. The chemical degradation of flazasulfuron on various dry minerals (calcium bentonite, kaolinite, silica, montmorillonite, and alumina) was investigated at 30 °C. The rearrangement reaction is the only one observed in the presence of kaolinite and alumina. However, hydrolysis and rearrangement have the same reaction rate in the presence of silica. The hydrolysis paths of flazasulfuron are comparable to the ones described for rimsulfuron.
- Bertrand, Cedric,Witczak-Legrand, Anne,Sabadie, Jean,Cooper, Jean-Francois
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p. 7717 - 7721
(2007/10/03)
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- N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-trifluoromethylpyridine-2-sulfonamide or salts thereof, herbicidal composition containing the same
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N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-3-trifluoromethylpyridine-2-sulfonamide or a salt thereof is disclosed. The compound of the invention is useful as a herbicide which has an extremely high herbicidal effect against a wide variety of weeds inc
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