A new synthesis of benzo [f]|isoindole-4,9-diones by radical alkylation and bromomethylation of 1,4-naphthoquinones
Two synthetic routes towards substituted benzo[f]isoindole-4,9-diones have been developed. One strategy relies on the synthesis of N-trifluoroacetyl- protected 2-(l-aminoalkyl)-1,4-naphthoquinones starting from 1,4-naphthoquinone and N-trifluoroacetyl-a-a