407-25-0

Basic information

• Product Name: Trifluoroacetic anhydride
• Synonyms: Aceticacid,trifluoro-,anhydride;Anhydrid kyseliny trifluoroctove;anhydridkyselinytrifluoroctove;Hexafluoroacetic anhydride;hexafluoroaceticanhydride;Perfluoroacetic anhydride;perfluoroaceticanhydride;TRIFLUOROACETIC ANHYDRIDE, REAGENTPLUS, >=99%
• CAS NO: 407-25-0
• Molecular Formula: C₄F₆O₃
• Molecular Weight: 210.03
• EINECS: 206-982-9
• Product Categories: Halogen compounds;Organics;Organic Fluorides;Acylation (GC Derivatizing Reagents);Analytical Chemistry;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;GC Derivatizing Reagents;Synthetic Organic Chemistry;organofluorine compound;Building Blocks;Carbonyl Compounds;Carboxylic Acid Anhydrides;Chemical Synthesis;Organic Building Blocks;Acylation Reagent;Pharmaceutical intermediates
• Mol File: 407-25-0.mol

Chemical Properties

• Melting Point: -63.5 °C
• Boiling Point: 39.5-40 °C(lit.)
• Flash Point: -26 °C
• Appearance: Clear/Liquid
• Density: 1.511 g/mL at 20 °C(lit.)
• Vapor Pressure: 6.28 psi ( 20 °C)
• Refractive Index: n20/D 1.3(lit.)
• Storage Temp.: 2-8°C
• Solubility: Miscible with benzene, dichloromethane, diethyl ether, dimethylf
• PKA: 0.43[at 20 ℃]
• Water Solubility: Hydrolysis
• Sensitive: Moisture Sensitive
• Stability: Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing a
• BRN: 746197
• CAS DataBase Reference: Trifluoroacetic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: Trifluoroacetic anhydride(407-25-0)
• EPA Substance Registry System: Trifluoroacetic anhydride(407-25-0)

Safety Data

• Hazard Codes: C,T
• Statements: 14-20-35-52/53-34-23/24/25
• Safety Statements: 26-36/37/39-43-45-61-9-8-28A-27
• RIDADR: UN 3265 8/PG 1
• WGK Germany: 2
• RTECS: AJ9800000
• F: 3-10
• TSCA: T
• HazardClass: 8
• PackingGroup: I
• Hazardous Substances Data: 407-25-0(Hazardous Substances Data)

Usage

Chemical Description

Trifluoroacetic anhydride is a reagent used for acylation reactions.

Uses

Used in Analytical Chemistry:
Trifluoroacetic anhydride is used as an analytical reagent for the introduction of trifluoroacetyl groups in organic synthesis. This modification is essential for the preparation of Nand O-trifluoroacetyl derivatives of a wide range of biologically active compounds, which are then subjected to gas chromatography analysis.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, trifluoroacetic anhydride is utilized as a dehydration condensing agent and a catalyst. Its role in the synthesis of various drugs and active pharmaceutical ingredients is crucial, as it aids in the formation of desired molecular structures.
Used in Agrochemical Industry:
Trifluoroacetic anhydride is employed in the agrochemical industry as an intermediate for the synthesis of various agrochemicals. Its ability to introduce trifluoroacetyl groups into organic compounds makes it a valuable component in the development of pesticides and other agricultural chemicals.
Used in Solvent Applications:
As a solvent, trifluoroacetic anhydride is used in various chemical reactions, providing a medium for the reactants to mix and interact. Its unique properties enable it to dissolve a wide range of substances, making it a versatile choice for many applications.
Used in Catalyst Applications:
Trifluoroacetic anhydride acts as a catalyst in the oxidation of aldehydes to acids, esters, and amides. It accelerates the reaction rate, allowing for more efficient and faster synthesis of the desired products.
Used in Protection Agent Applications:
Trifluoroacetic anhydride is used as a protection agent for alcohols and amines, preventing unwanted side reactions and ensuring the selective formation of the target compounds.
Used in Fluorine Fine Chemicals:
Trifluoroacetic anhydride serves as an intermediate in the synthesis of fluorine fine chemicals, which are essential components in various industrial applications, including the production of specialty materials and advanced technologies.

Safety Profile

A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit

Purification Methods

Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

InChI:InChI=1/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10

Synthetic route

N-(n-butyl)-2,4-dinitrotrifluoroacetanilide (64899-09-8) → 2,4-dinitro-N-butylaniline (13059-86-4) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With tris buffers; cetyltrimethylammonim bromide at 25℃; Rate constant; hydrolysis, other quaterner amines;	A 99.7% B n/a

trifluoroacetic acid (76-05-1) → trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With fuming sulphuric acid at 130℃; Large scale;	99%
With fuming sulphuric acid at 78 - 130℃; Large scale;	99%
With sulfuric acid; sulfur trioxide at 130℃;	99%

trifluoromethyldiiodophosphine (421-59-0) + silver trifluoroacetate (2966-50-9) → Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid (1682-76-4) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
within 10 h;	A n/a B 98%
10 min; isolation from volatile part of product;	A n/a B 72%

trifluorormethanesulfonic acid (1493-13-6) + trifluoroacetic acid (76-05-1) → trifluoroacetic anhydride (407-25-0) + trifluoroacetyl triflate (68602-57-3)

Conditions	Yield
With phosphorus pentoxide at -20 - 240℃; for 3.5h;	A n/a B 75%

Cl2SNTeF5 (86024-51-3) + silver trifluoroacetate (2966-50-9) → F5TeNSO (86024-52-4) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
In neat (no solvent) Cl2S=NTeF5 and CF3COOAg stirred at room temp. and warmed to 45°Cand stirred for 1 h; O=S=NTeF5 and (CF3CO)2O condensed into -196°C trap under vac., separation achieved by trap-to-trap distillation through -45 (O=S=NTeF5) and -78°C cooled traps; elem. anal.;	A 68% B n/a

2,2,2-trifluoroethyl trifluoroacetate (407-38-5) → Carbonyl fluoride (353-50-4) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With chlorine at 22.84℃; under 760 Torr; Irradiation; Synthetic gas;	A 35% B 45%

mercury(II) trifluoroacetate (13257-51-7) + chloro(chlorosulfanyl)methanone (2757-23-5) → trifluoroacetic anhydride (407-25-0)

Conditions	Yield
at 50 - 55℃; for 3h;	30%

O,O-Diethyl O-Trifluoroacetyl Phosphate (650-09-9) → Tetraethyl pyrophosphate (107-49-3) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Erhitzen im Vakuum;

tris(trifluoro acetyloxy)borane (350-70-9) → tetrakis-trifluoroacetoxy-diboroxane (330-25-6) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
at 100℃; under 0.0001 Torr;
at 100℃; under 0.0001 Torr;

silver trifluoroacetate (2966-50-9) → trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With phosphorus at 180℃;
With sulfur at 300℃;

calcium bistrifluoroacetate (60884-90-4) → trifluoroacetyl fluoride (354-34-7) + trifluoroacetic anhydride (407-25-0)

trifluoroacetic acid (76-05-1) → trifluoroacetyl fluoride (354-34-7) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Erhitzen des Lithium-Salzes;

Bis(trifluormethyl)phosphinigsaeure-trifluoressigsaeureanhydrid (2377-97-1) → Tetrakis(trifluormethyl)disphosphoxan (2728-67-8) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
at 40℃; Equilibrium constant;
within 24 h;
equil.;

trifluoromethyl isocyanide (19480-01-4) + trifluoroacetic acid (76-05-1) → N-(trifluoromethyl)formamide (109975-95-3) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Ambient temperature; Yield given. Yields of byproduct given;

trifluoroacetic acid (76-05-1) + trifluoroacetyl triflate (68602-57-3) → trifluorormethanesulfonic acid (1493-13-6) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Equilibrium constant;

N-Allyl-9-anthracenemethanimine (72925-88-3) → 2-(Trifluoroacetyl)-1,2,3,3a,4,5-hexahydro-5,9b-o-benzenobenzisoindol-1-ol (72917-92-1, 72917-93-2, 344598-97-6) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
In dichloromethane for 24h; Ambient temperature; Title compound not separated from byproducts;

3,6-dehydrohomoadamantane (26525-13-3) + chromyl trifluoroacetate (27184-84-5) → trifluoroacetic anhydride (407-25-0) + 3-oxobicyclo[3.3.1]nonane-7-spirocyclopropane + Trifluoro-acetic acid 6-hydroxy-tricyclo[4.3.1.13,8]undec-3-yl ester

Conditions	Yield
In tetrachloromethane at 0℃; for 0.5h;	A 17 % Spectr. B 34 % Spectr. C 42 % Spectr.

Caesium; 2,3,3,3-tetrafluoro-2-methoxy-propionate (129880-36-0) → Carbonyl fluoride (353-50-4) + trifluoroacetyl fluoride (354-34-7) + methyl 1,2,2-trifluorovinyl ether (3823-94-7) + 2-fluoro-2-methoxy trifluoropropanoic acid methyl ester (10186-63-7) + α-methoxytetrafluoropropionyl fluoride (85036-47-1) + trifluoroacetic anhydride (407-25-0) + CsF, CO2, CH3F

Conditions	Yield
at 250℃; under 0.01 Torr; for 1.5h; Product distribution; Mechanism;

iodine (7553-56-2) + silver trifluoroacetate (2966-50-9) + benzene (71-43-2) → iodobenzene (591-50-4) + trifluoroacetic anhydride (407-25-0)

iodo-bis-trifluoromethyl-phosphine (359-64-8) + silver trifluoroacetate (2966-50-9) → Bis(trifluormethyl)phosphinigsaeure-trifluoressigsaeureanhydrid (2377-97-1) + Tetrakis(trifluormethyl)disphosphoxan (2728-67-8) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
byproducts: AgI; below 20°C; further react. in equil.; distn.; main product as medium fraction at 0°C / 55 Torr;

Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid (1682-76-4) → Tetrakis(trifluormethyl)disphosphoxan (2728-67-8) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
18.5 degree.C; equil.; value for equil. const. given at 40°C;

Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid (1682-76-4) → trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With (CH3)3N formation from unidentified intermediate product;

yttrium trifluoroacetate → yttrium(III) fluoride (13709-49-4) + carbon dioxide (124-38-9) + carbon monoxide (201230-82-2) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With O2 or Ar In neat (no solvent) decompn. at 300 ° C in Ar and at 230-270 ° C in O2; YF3 formed;

(trifluoro methyl) tris-(trifluoro acetoxy) germane → carbon dioxide (124-38-9) + germanium dioxide + silicon tetrafluoride (7783-61-1) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
In neat (no solvent) pyrolysis at 240°C within 24 hours;;

ethyl trifluoroacetate, (383-63-1) + hydrazine (302-01-2) → 1,2-bis(trifluoroacetyl)hydrazine (667-35-6) + trifluoroacetic acid (76-05-1) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
In ethanol dropping of soln. of CF3COOC2H5 in abs. alc. to N2H4 soln. in anhydrous C2H5OH by cooling, stirring at 20°C (12 h); evapn. of C2H5OH, stirring at 20°C (12 h);

S-trifluoromethylcarbonothioic trifluoroacetic anhydride (67756-31-4) → S,S'-Bis(trifluormethyl)dithiocarbonat (51615-93-1) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Irradiation (UV/VIS); photolysis;
Irradiation (UV/VIS); photolysis;

Trifluoromethyliodine(III) bis-trifluoroacetate (60669-28-5) → iodotrifluoromethane (2314-97-8) + trifluoromethyliodine dioxide (56407-84-2) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
above -6°C;

pyrrole (109-97-7) + trifluoroacetic anhydride (407-25-0) → 2-(trifluoroacetyl)pyrrole (2557-70-2)

Conditions	Yield
	100%
With benzene
With 1H-imidazole

4-chloro-aniline (106-47-8) + trifluoroacetic anhydride (407-25-0) → N-(4-chlorophenyl)-2,2,2-trifluoroacetamide (404-25-1)

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	88%
In diethyl ether for 1h; Ambient temperature;	84%

4-methoxy-aniline (104-94-9) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(4-methoxy-phenyl)-acetamide (332-34-3)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃;	100%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h;	100%
at 20℃; for 1h;	98.3%

isopropylamine (75-31-0) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(1-methylethyl)acetamide (348-76-5)

Conditions	Yield
With pyridine; dmap In tetrahydrofuran at 20℃; for 15h;	100%
With diethyl ether
In diethyl ether
at 0℃; than Rt, 3 h;
In dichloromethane at 20℃; Inert atmosphere; Schlenk technique; Glovebox;

p-cresol (106-44-5) + trifluoroacetic anhydride (407-25-0) → 4-methylphenyl trifluoroacetate (1813-29-2)

Conditions	Yield
erbium(III) triflate In acetonitrile at 20℃; for 8h;	100%
at 100℃; Cooling with ice;	93%

trifluoroacetic anhydride (407-25-0) + benzyl alcohol (100-51-6) → benzyl trifluoroacetate (351-70-2)

Conditions	Yield
erbium(III) triflate In acetonitrile at 20℃; for 0.166667h;	100%
With erbium(III) chloride for 2h; Heating;	99%
In diethyl ether at 0℃; for 2h; Inert atmosphere;	95%

trifluoroacetic anhydride (407-25-0) → trifluoroacetic acid-d1 (599-00-8)

Conditions	Yield
With water-d2 at -78℃;	100%
With water-d2
With water-d2 1.) 0 deg C, 2.) reflux, 30 min;

m-Anisidine (536-90-3) + trifluoroacetic anhydride (407-25-0) → N-(3-methoxyphenyl)-2,2,2-trifluoroacetamide (14818-55-4)

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h;	100%
In diethyl ether
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
With triethylamine
at 20℃; for 3h; Inert atmosphere;

2-methoxy-phenylamine (90-04-0) + trifluoroacetic anhydride (407-25-0) → N-(2-methoxyphenyl)-2,2,2-trifluoro-acetamide (14815-12-4)

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h;	100%
With pyridine In dichloromethane at 0 - 20℃; for 72h; Inert atmosphere;	99%
In diethyl ether
Stage #1: 2-methoxy-phenylamine With pyridine In dichloromethane at 0℃; for 0.5h; Stage #2: trifluoroacetic anhydride In dichloromethane at 0 - 30℃; for 1.25h;
With pyridine In dichloromethane at 0 - 20℃; for 1.25h;

anthranilic acid (118-92-3) + trifluoroacetic anhydride (407-25-0) → 2-trifluoromethyl-4H-3,1-benzoxazin-4-one (16062-71-8)

Conditions	Yield
In neat (no solvent) at 130℃; for 6h; Sealed tube; Inert atmosphere;	100%
In chloroform for 1h; Reflux;	56%
In ethyl acetate

2,3-Dimethylaniline (87-59-2) + trifluoroacetic anhydride (407-25-0) → N-(2,3-dimethylphenyl)-2,2,2-trifluoroacetamide (14719-31-4)

Conditions	Yield
In dichloromethane for 1h; Further stages;	100%
With triethylamine In dichloromethane for 1h; Ambient temperature;	87%
In diethyl ether
In dichloromethane at 0 - 20℃; for 12h;

cholesterol (57-88-5) + trifluoroacetic anhydride (407-25-0) → cholesteryl trifluoroacetate (2665-02-3)

Conditions	Yield
erbium(III) triflate In acetonitrile at 20℃; for 4h;	100%

tirucallol (79-63-0) + trifluoroacetic anhydride (407-25-0) → Lanosterin-trifluoracetat (10112-12-6)

Conditions	Yield
With pyridine; dmap In dichloromethane at 0℃; for 0.333333h;	100%

L-cystine dimethyl ester dihydrochloride (32854-09-4) + trifluoroacetic anhydride (407-25-0) → N,N'-bis(trifluoroacetyl)-L-cystine dimethyl ester (1492-83-7)

Conditions	Yield
With trifluoroacetic acid at -5 - 20℃;	100%
In trifluoroacetic acid Ambient temperature;	98%
	90%
In trifluoroacetic acid

1-indoline (496-15-1) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-1-(indolin-1-yl)ethan-1-one (90732-28-8)

Conditions	Yield
With triethylamine In dichloromethane	100%
In dichloromethane at 0℃; for 1h; Inert atmosphere;	100%
In benzene at 0 - 5℃;	96%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + trifluoroacetic anhydride (407-25-0) → 1-(3,4-dihydroquinolin-1(2H)-yl)-2,2,2-trifluoroethanone (79066-90-3)

Conditions	Yield
With triethylamine In diethyl ether at 0 - 20℃; for 5h;	100%
With triethylamine In diethyl ether at 20℃; for 5h;	100%
With triethylamine In diethyl ether at 0 - 20℃;	98%

4,6-di-O-acetyl-3-O-methyl-D-glucal (60584-32-9, 124579-82-4) + trifluoroacetic anhydride (407-25-0) → Trifluoro-acetic acid (4R,5S,6R)-5-acetoxy-6-acetoxymethyl-4-methoxy-3-nitro-tetrahydro-pyran-2-yl ester (102634-07-1, 102634-08-2, 102634-09-3, 102649-49-0)

Conditions	Yield
With ammonium nitrate for 1h;	100%

N-(3,4-Dimethoxyphenylacetyl)tryptamine (86296-23-3) + trifluoroacetic anhydride (407-25-0) → C24H18F6N2O4

Conditions	Yield
In benzene 1) 0 degC, 3 h, 2) 20 degC, 1 h;	100%

1-(3-aminophenyl)ethanone (99-03-6) + trifluoroacetic anhydride (407-25-0) → 3-trifluoroacetamidoacetophenone (56915-87-8)

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 0.5h;	100%
In N,N-dimethyl-formamide for 48h; Ambient temperature;	80%
With trifluoroacetic acid Heating;

3-trifluoromethylaniline (98-16-8) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(3-(trifluoromethyl)phenyl)acetamide (2946-73-8)

Conditions	Yield
With triethylamine In 2-methyltetrahydrofuran	100%
Stage #1: 3-trifluoromethylaniline; trifluoroacetic anhydride With pyridine In dichloromethane at 0 - 20℃; Stage #2: With sodium hydrogencarbonate In dichloromethane	98%
In N,N-dimethyl-formamide for 48h; Ambient temperature;	70%
With triethylamine In tetrahydrofuran at 0 - 20℃;	51.1%
In dichloromethane

benzotriazol-1-ol (2592-95-2) + trifluoroacetic anhydride (407-25-0) → 1-trifluoroacetoxybenzotriazole

Conditions	Yield
for 0.5h;	100%

2-(5,8-Dimethoxy-quinolin-4-yl)-phenylamine (114552-24-8) + N-ethyl-N,N-diisopropylamine (7087-68-5) + trifluoroacetic anhydride (407-25-0) → N-[2-(5,8-Dimethoxy-quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide (114552-23-7)

Conditions	Yield
at 0℃; for 0.5h;	100%

3-nitro-aniline (99-09-2) + trifluoroacetic anhydride (407-25-0) → N-trifluoroacetic-3-nitroaniline (25080-83-5)

Conditions	Yield
In pyridine; dichloromethane	100%
With pyridine In dichloromethane at 20℃; for 3h;	95%
In acetonitrile for 2h; Ambient temperature;

4-Methyl-2H-1,4-thiazin-3-one (65197-65-1) + trifluoroacetic anhydride (407-25-0) → 6-Trifluoroacetyl-4-methyl-2H-1,4-thiazin-3-one (82912-54-7)

Conditions	Yield
With pyridine In chloroform for 1080h; Ambient temperature;	100%

2-methyl-8-nitroindolizine (60891-78-3) + trifluoroacetic anhydride (407-25-0) → 2,2,2-Trifluoro-1-(2-methyl-8-nitro-indolizin-3-yl)-ethanone (115058-17-8)

Conditions	Yield
	100%

1,2-O-isopropylidene-3-amino-3,5-dideoxy-α-D-ribofuranoside (39798-26-0) + trifluoroacetic anhydride (407-25-0) → 3,5-dideoxy-3-(trifluoroacetamido)-1,2-O-isopropylidene-α-D-ribofuranose (39798-31-7)

Conditions	Yield
In diethyl ether 1.) 0 deg C, 0.5 h, 2.) RT, 30 min;	100%

N,N-dimethyl-1-naphthalenamine (86-56-6) + trifluoroacetic anhydride (407-25-0) → N,N-Dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine (115975-33-2)

Conditions	Yield
With pyridine In chloroform for 18h; Ambient temperature;	100%
With pyridine In chloroform for 19h; Ambient temperature; 2.5 eq. (CF3CO)2O;

2,3,4,6-tetra-O-benzyl-D-glucopyranose (6564-72-3) + trifluoroacetic anhydride (407-25-0) → 2,3,4,6-tetra-O-benzyl-1-O-(trifluoroacetyl)-α-D-glucopyranose (125343-69-3)

Conditions	Yield
With sodium 2,2,2-trifluoroacetate for 0.5h; Heating;	100%

3,4,6-tri-O-acetyl-D-glucal (52485-06-0) + trifluoroacetic anhydride (407-25-0) → Trifluoro-acetic acid (4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-nitro-tetrahydro-pyran-2-yl ester (102633-91-0, 102633-92-1, 102633-93-2, 102633-94-3, 102633-95-4, 102633-96-5, 102633-97-6, 102633-98-7, 102633-99-8, 102634-00-4, 102634-01-5, 102634-02-6)

Conditions	Yield
With ammonium nitrate for 1h;	100%

octanol (111-87-5) + trifluoroacetic anhydride (407-25-0) → n-octyl trifluoroacetate (2561-21-9)

Conditions	Yield
erbium(III) triflate In acetonitrile at 20℃; for 2.5h;	100%
With erbium(III) chloride for 1.5h; Heating;	99%
With triethylamine In benzene at 25 - 30℃; for 1h;

Upstream product

• 650-09-9 O,O-Diethyl O-Trifluoroacetyl Phosphate 
• 350-70-9 tris(trifluoro acetyloxy)borane 
• 2966-50-9 silver trifluoroacetate 
• 60884-90-4 calcium bistrifluoroacetate 
• 76-05-1 trifluoroacetic acid 
• 2377-97-1 Bis(trifluormethyl)phosphinigsaeure-trifluoressigsaeureanhydrid 
• 64899-09-8 N-(n-butyl)-2,4-dinitrotrifluoroacetanilide 
• 13257-51-7 mercury(II) trifluoroacetate 
• 2757-23-5 chloro(chlorosulfanyl)methanone 
• 19480-01-4 trifluoromethyl isocyanide 
• 68602-57-3 trifluoroacetyl triflate 
• 72925-88-3 N-Allyl-9-anthracenemethanimine 
• 26525-13-3 3,6-dehydrohomoadamantane 
• 27184-84-5 chromyl trifluoroacetate 

Downstream Products

• 360-31-6 trifluoro-acetic acid thiazol-2-ylamide 
• 457-50-1 2,2,2-trifluoro-n-pyridin-2-yl-acetamide 
• 3820-88-0 1-cyclohexyl-4-trifluoroacetyl-piperazine 
• 2557-70-2 2-(trifluoroacetyl)pyrrole 
• 1692-78-0 1-phenyl-4-trifluoroacetyl-piperazine 
• 3848-73-5 1-p-tolyl-4-trifluoroacetyl-piperazine 
• 71132-72-4 1-phenyl-3-methyl-4-trifluoroacetyl-pyrazolone-5 
• 2803-00-1 N-trifluoroacetyl,N-benzyl piperazine 
• 100517-53-1 3-hydroxy-quinoline-4-carbonitrile 
• 63158-99-6 2-oxo-1,2-dihydro-quinoline-4-carbonitrile 
• 501-84-8 trifluoro-acetic acid-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylamide) 
• 3869-96-3 1-(4-chloro-phenyl)-4-trifluoroacetyl-piperazine 
• 899-95-6 4-trifluoroacetyl-piperazine-1-carboxylic acid benzyl ester 
• 1717-77-7 2,2,2-trifluoro-1-[4-(4-nitro-phenyl)-piperazin-1-yl]-ethanone 

Relevant articles and documents

Some fluorinated heterocyclic and acyclic derivatives of chlorocarbonylsulfenyl chloride

For the first time, fluorinated oxathialones, polyfluoroalkylchlorothioformates, chlorocarbonylpolyfluoroalkylsulfenate esters, a chlorocarbonylhexafluoroisopropylidenimino sulfenate, and a 5-tri-fluoromethyl-2-oxo-1,3,4-oxathiazole were synthesized by reacting chlorocarbonylsulfenyl chloride with RfC(O)CH2C(O)R′ (Rf = CF3; R'= CF3, OC2H5), RfO-Li+ (Rf = CF3CH2, (CF3)2C=N-Li+ and CF3C(O)NH2. Perfluorosuccinic acid and mercury(II) trifluoroacetate with ClC(O)SCI gave their respective anhydrides.

Backside activation of σ(c-c)-bonds with Cr(VI)-reagents

The transformations of stable propellanes 3,6-dehydrohomoadamantane (1) and 1,5-dehydrobicyclo[3.3.1]nonane (2) on treatment with chromyl oxidants in different solvents were studied. Hydrocarbon 1 with CrO2Cl2 in nonpolar solvents forms 3,6-dichloro- (3) and 3-chloro-6-hydroxy- (4) homoadamantanes in the course of backside oxidative addition. to the strained C-C bond and 3-oxobicyclo[3.3.1]nonane-7-spirocyclopropane (5) as a result of the oxidative cyclobutane ring contraction. CrO2(OAc)2/Ac2O and CrO2(OCOCF3)2/(CF3CO)2O result only in oxidative addition with the formation of the mixtures of the corresponding 6-hydroxy-3-acetates (7,9) and 3,6-diacetates (6,8). In the case of 2 the only oxidative addition takes place. Possible mechanisms of the backside oxidative addition to the C-C bond are discussed.

METHOD OF PREPARING HALOGENATED CARBOXYLIC ANHYDRIDES

PROBLEM TO BE SOLVED: To provide a method for producing halogenated carboxylic anhydrides wherein: improved yield and/or purity of a product can be obtained; waste and/or by-products are easily separated from the product of the method; and/or the toxicity is reduced and/or environmental damage is reduced. SOLUTION: Trifluoroacetate acid anhydrides are prepared by, for example, reacting trifluoroacetate with sulfuric acid, oleum and/or disulfate. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPO&INPIT

REDUCTION OF CONTENT OF CARBOXYLIC ACIDS AND DERIVATIVES THEREOF IN OLEUM, DISULFURIC ACID OR CONCENTRATED SULFURIC ACID

The present invention concerns a process for the reduction of content of carboxylic acids and derivatives thereof in oleum, disulfuric acid or concentrated sulfuric acid. The invention further concerns a process for the manufacture of carboxylic acid anhydrides comprising the process for the reduction of content of carboxylic acids and derivatives thereof from oleum, disulfuric acid or concentrated sulfuric acid.

A process for preparing trifluoroacetic anhydride method

The invention discloses a method for preparing trifluoroacetic anhydride. A dry chemical inert solvent, white solid powdery phosphorus pentoxide and an absorbent dried and activated at the temperature of 100-130 DEG C in advance are added to a dry reaction kettle, the mixture is uniformly mixed and dispersed through mechanical stirring; trifluoroacetic acid is dropped, then the mixture is heated, subjected to reflux to have a reaction for several hours and distilled under common pressure, so that front cut fraction at the temperature of 39-50 DEG C is obtained, the obtained front cut fraction is rectified through a rectifying column, and then a reagent-grade product at the temperature of 39 DEG C-40.5 DEG C is obtained; finally, rear cut fraction higher than 50 DEG C is collected, water or a phosphoric acid aqueous solution is dropped to residues containing unreacted phosphorus pentoxide solids after the reaction, and retreatment is performed after the reaction kettle is cooled. Raw materials are cheap and easy to obtain, the solvent can be recycled, the cost is low, economic benefits are high, and the operation is standard and safe.

PROCESS FOR THE PREPARATION OF HALOGENATED CARBOXYLIC ANHYDRIDES

The present invention relates to a process for the preparation of halogenated carboxylic anhydrides, e.g. for the preparation of trifluoroacetic anhydride. The preparation is achieved by reacting a halogenated carboxylic acid, e.g. trifluoroacetic acid, with sulfuric acid, oleum and/or disulfuric acid.

Process for the preparation of halogenated carboxylic anhydrides

The present invention relates to a process for the preparation of halogenated carboxylic anhydrides, e.g. for the preparation of trifluoroacetic anhydride. The preparation is achieved by reacting a halogenated carboxylic acid, e.g. trifluoroacetic acid, with sulfuric acid, oleum and/or disulfuric acid.

USE OF PEPTIDIC VASOPRESSION RECEPTOR AGONISTS

The present invention relates to the use of novel compounds for the manufacture of a medicament for treatment of inter alia conditions associated with critical care as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds utilised are represented by the general formula (I), as further defined in the specification.

MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF

Compounds with α7 nicotinic acetylcholine receptor (α7 nAChR) agonistic activity, processes for their preparation, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological and psychiatric diseases.

NOVEL MULTIMERIC CD40 LIGANDS, METHOD FOR PREPARING SAME AND USE THEREOF FOR PREPARING DRUGS

The invention concerns a compound of formula (I), wherein Y represents a macrocycle whereof the cycle comprises 9 to 36 atoms, and is functionalized by three amine or COOH functions; Rc represents a group of formula H—Xa—Xb—Xc—Xd—Xe—(Xf)i—, wherein i represents 0 or 1, Xn is in particular selected among lysine, arginine, ornithine residues, Xb is in particular selected among glycine, asparagine, L-proline or D-proline residues, Xc et Xd are in particular selected among tyrosine, phenylalanine or 3-nitrotyrosine residues, Xe et Xf are in particular selected among the following amino acid residues: NH2—(CH2)n—COOH, n ranging from 1 to 10 or NH2—(CH2—CH2—O)m—CH2CH2COOH, m ranging from 3 to 6, provided that one at least of the amino acid residues Xa, Xb, Xc and Xd is different from the corresponding amino acid in the sequence of the natural CD40 143Lys-Gly-Tyr-Tyr146 fragment