104051-62-9 Usage
Chemical structure
A complex organic molecule with a 1,8-naphthyridine core, a fluorinated phenyl group, a piperazinyl group, and a fluoro substituent.
Functional groups
Carboxylic acid, ethyl ester, phenyl, piperazinyl, and fluoro substituents.
Molecular weight
Approximately 431.39 g/mol
Appearance
Likely a solid or crystalline substance, though the exact appearance is not provided.
Solubility
The solubility is not specified, but it is likely soluble in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO) due to its ester and aromatic components.
Stability
The stability of the compound is not explicitly mentioned, but it is expected to be stable under normal laboratory conditions.
Pharmaceutical applications
Potential use in the treatment of bacterial infections due to its antibacterial properties.
Drug discovery
A potential candidate for the development of antimicrobial agents.
Synthesis
The synthesis of 1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, ethyl ester likely involves the formation of the 1,8-naphthyridine core, followed by the introduction of the various functional groups, including the fluorinated phenyl group, the piperazinyl group, and the fluoro substituent. The final step would be the formation of the ethyl ester derivative.
Mechanism of action
The specific mechanism of action is not provided, but it is likely that the compound targets bacterial enzymes or cellular processes, leading to the inhibition of bacterial growth or cell death.
Safety and toxicity
Information on safety and toxicity is not provided, but it is essential to consider these factors when developing new pharmaceutical agents.
Check Digit Verification of cas no
The CAS Registry Mumber 104051-62-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,0,5 and 1 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 104051-62:
(8*1)+(7*0)+(6*4)+(5*0)+(4*5)+(3*1)+(2*6)+(1*2)=69
69 % 10 = 9
So 104051-62-9 is a valid CAS Registry Number.
104051-62-9Relevant articles and documents
RIFAMYCIN DERIVATIVES EFFECTIVE AGAINST DRUG-RESISTANT MICROBES
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Page/Page column 38, (2010/02/13)
Rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms are claimed in this invention. The inventive rifamycin derivatives are uniquely designed in that they have a rifamycin moiety covalently linked to a linker group through the C-3 carbon of the rifamycin moiety and the linker is, in turn covalently linked to a therapeutic moiety or antibacterial agent/pharmacophore. The therapeutic moiety can be a quinolone, an oxazolidinone, a macrolide, an aminoglycoside, a tetracycline core or a structure/pharmacophore associated with an antibacterial agent.
Process for producing 1-substituted aryl-1,4-dihydro-4-oxonaphthyridine derivatives, and processes for producing the intermediates
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, (2008/06/13)
This invention relates to a process for industrially producing a 1-substituted aryl-1,4-dihydro-4-oxonaphthyridine derivative and a salt thereof which are useful as an antibacterial agent, and also to intermediates therefor and processes for producing the
Synthesis and Structure-Activity Relationships of New Arylfluoronaphthyridine Antibacterial Agents
Chu, Daniel T. W.,Fernandes, Prabhavathi B.,Claiborne, Akiyo K.,Gracey, Eugene H.,Pernet, Andre G.
, p. 2364 - 2369 (2007/10/02)
Novel arylfluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid have been prepared and their antibacterial activity evaluated.These derivatives are characterized by having a fluorine atom at 6-position, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.The in vitro antibacterial potency is greatest when the 1-substituent is either p-fluorophenyl or o,p-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-amino-1-pyrrolidinyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (38) was found to possess excellent in vitro potency and in vivo efficacy.
