- Preparation process of atipamezole hydrochloride
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The invention relates to the technical field of preparation of compounds, in particular to a preparation process of atipamezole hydrochloride. The preparation process comprises the following operationsteps: 1) reacting 4-(2-ethyl-2-indanone) imidazole and alkali in an organic solvent; 2) adding hydrazine hydrate into the reaction solution obtained in the step 1) to obtain atemeconazole; and 3) adding the atemeconazole obtained in the reaction 2) into concentrated hydrochloric acid for salifying to obtain atemeconazole hydrochloride. At present, the industrial synthesis of the atemeconazole hydrochloride in the prior art is low in yield and high in cost; the invention provides a brand-new preparation process of the atenomezole, which effectively improves the reaction efficiency, synthesizes the atenomezole with high selectivity, reduces byproducts, effectively reduces the discharge of waste water and waste gas and is beneficial to industrial production.
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Paragraph 0029; 0031; 0033; 0035; 0037
(2020/12/08)
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- PROCESS FOR THE PREPARATION OF 5-(2-ETHYL-DIHYDRO-1H-INDEN-2-YL)-1H-IMIDAZOLE AND SALTS THEREOF
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The invention provides an improved, highly efficient method for preparing 5-(2- ethyl-2,3-dihydro-1 H-inden-2-yl)-1 H-imidazole, and its salts, in particular its pharmaceutically acceptable salts.
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Page/Page column 8-9
(2009/07/17)
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