- Studies on the antioxidant activity of some thiazolidinedione, imidazolidinedione and rhodanine derivatives having a flavone core
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A series of flavonyl-2,4-thiazolidinedione, imidazolidinedione and rhodanine derivatives were tested for their antioxidant activity as scavengers of oxygen free radicals. Free radical scavenging activities, including superoxide anion radical (O-2), hydroxyl radical (HO?) and 2,2′-diphenyl-1-picrylhydrazyl free radical have been evaluated using chemiluminescence, electron paramagnetic resonance and spin trapping with 5,5-dimethyl-1-pyrroline-1-oxide as a spin trap. Potassium superoxide in dimethylsulfoxide and 18-crown-6 ether were used for the production of O-2. Hydroxyl radical was generated using the Fenton reaction. Ten of the eleven examined compounds exhibited decrease in chemiluminescence, but there were large differences in the decrease, ranging from 16% to 89%; also, two of these compounds increased light emission by about 200%. On the contrary, all compounds tested exhibited 30-68% scavenging HO? and 25-96% scavenging the DPPH radical respectively. Possible mechanisms are proposed to explain the results.
- Berczyński, Pawe?,K?adna, Aleksandra,Piechowska, Teresa,Kruk, Irena,Bozda?-Dündar, Oya,Aboul-Enein, Hassan Y.,Ceylan-Unlusoy, Meltem,Ertan, Rahmiye
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p. 1107 - 1112
(2015/02/19)
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- Synthesis and hypoglycemic activity of some new flavone derivatives: 4th communication: 6-flavonyl-2,4-thiazolidinediones
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A new series of flavonyl compounds (1-10) was prepared and tested for their insulinotropic activities in INS-1 cells. Compounds 2, 5 and 6 (at higher concentrations) and compounds 3 and 7-10 were able to increase insulin release in the presence of 5.6 mmo
- Bozdag-Duendar,Waheed,Verspohl,Ertan
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p. 623 - 627
(2007/10/03)
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