- Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum
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The first total syntheses of the natural products lobaric acid (1) and its derivatives isolated from the Antarctic lichen Stereocaulon alpinum are reported in this study. Lobarin (3), with a pseudodepsidone structure, was synthesized first in 11 steps by utilizing an Ullmann aryl ether coupling reaction, and lobaric acid was synthesized in an additional three steps by a seven-membered lactonization reaction. Various derivatives were also obtained from the prepared lobaric acid, and the synthetic compounds exhibited significant PTP1B inhibitory activities.
- Kim, Tai Kyoung,Kim, Joung Eun,Youn, Ui Joung,Han, Se Jong,Kim, Il-Chan,Cho, Cheon-Gyu,Yim, Joung Han
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- CANNABINOID DERIVATIVES
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The present disclosure relates to a carmabinoid derivative, a pharmaceutical composition comprising it, as well as its use in the treatment and prevention of diseases associated with a carmabinoid receptor in a subject in need thereof, such as acute pain, ADHD/ ADD, alcohol use disorder, allergic asthma, ALS, Alzheimer's, anorexia, etc. The carmabinoid derivative has the following formula:
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Paragraph 0138
(2021/01/23)
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- Synthesis and antibacterial evaluation of anziaic acid and its analogues as topoisomerase i inhibitors
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Naturally occurring anziaic acid has very recently been reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and its structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.
- Lin, Hao,Annamalai, Thirunavukkarasu,Bansod, Priyanka,Tse-Dinh, Yuk-Ching,Sun, Dianqing
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supporting information
p. 1613 - 1618
(2013/12/04)
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- Synthesis of Further Divarinol and Olivetol Lichen para-Depsides
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The lichen depsides 2-O-methyldivaricatic acid (1), 3-chlorodivaricatic acid (2), 4-O-demethylstenoporic acid (3), 2-O-methylstenosporic acid (4), 4-O-demethylimbricaric acid (5) and 3,5-dichloro-2'-O-methylanziaic (6) have been prepared by unambigous syn
- Elix, John A.,Parker, John L.,Tearne, Philip D.,Wardlaw, Judith H.
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p. 1863 - 1871
(2007/10/02)
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