104307-50-8Relevant academic research and scientific papers
Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum
Kim, Tai Kyoung,Kim, Joung Eun,Youn, Ui Joung,Han, Se Jong,Kim, Il-Chan,Cho, Cheon-Gyu,Yim, Joung Han
, p. 1460 - 1467 (2018)
The first total syntheses of the natural products lobaric acid (1) and its derivatives isolated from the Antarctic lichen Stereocaulon alpinum are reported in this study. Lobarin (3), with a pseudodepsidone structure, was synthesized first in 11 steps by utilizing an Ullmann aryl ether coupling reaction, and lobaric acid was synthesized in an additional three steps by a seven-membered lactonization reaction. Various derivatives were also obtained from the prepared lobaric acid, and the synthetic compounds exhibited significant PTP1B inhibitory activities.
CANNABINOID DERIVATIVES
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Paragraph 0138, (2021/01/23)
The present disclosure relates to a carmabinoid derivative, a pharmaceutical composition comprising it, as well as its use in the treatment and prevention of diseases associated with a carmabinoid receptor in a subject in need thereof, such as acute pain, ADHD/ ADD, alcohol use disorder, allergic asthma, ALS, Alzheimer's, anorexia, etc. The carmabinoid derivative has the following formula:
Synthesis and antibacterial evaluation of anziaic acid and its analogues as topoisomerase i inhibitors
Lin, Hao,Annamalai, Thirunavukkarasu,Bansod, Priyanka,Tse-Dinh, Yuk-Ching,Sun, Dianqing
supporting information, p. 1613 - 1618 (2013/12/04)
Naturally occurring anziaic acid has very recently been reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and its structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.
Synthesis of Further Divarinol and Olivetol Lichen para-Depsides
Elix, John A.,Parker, John L.,Tearne, Philip D.,Wardlaw, Judith H.
, p. 1863 - 1871 (2007/10/02)
The lichen depsides 2-O-methyldivaricatic acid (1), 3-chlorodivaricatic acid (2), 4-O-demethylstenoporic acid (3), 2-O-methylstenosporic acid (4), 4-O-demethylimbricaric acid (5) and 3,5-dichloro-2'-O-methylanziaic (6) have been prepared by unambigous syn
