- Bicyclo-imidazoline laurate, synthesis method therefor and application of bicyclo-imidazoline laurate
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The invention discloses bicyclo-imidazoline laurate. The bicyclo-imidazoline laurate has a symmetrical molecular structure, comprises two imidazoline heterocycles and two alkyl long chains of lauric acid, and thus, plenty and dense electronic clouds and good hydrophobicity can be provided. The invention further discloses a bicyclo-imidazoline laurate synthesis method, which is low in raw materialcost and high in reaction yield and can achieve industrial production. The invention further discloses an application of the bicyclo-imidazoline laurate. The electrotransport type cationic bicyclo-imidazoline laurate is obtained through activating bicyclo-imidazoline laurate and is applied to the rusting prevention of reinforced concrete.
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- Synthesis of aldehydes from carboxylic acids via 2-imidazolines
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The use of readily available 2-substituted-2-imidazolines as precursors to 2-hydroxy aldehyde, unsaturated aldehyde and a variety of functionalized aldehydes is reported. It provides a novel method for the preparation of aldehydes from carboxylic acids via 2-substituted-2-imidazolines.
- Shi, Zhen,Gu, Huan
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p. 2701 - 2707
(2007/10/03)
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- Compositions and method comprising heterocyclic compounds containing two heteroatoms as membrane penetration enhancers
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A method and compositions for enhancing absorption of topically administered physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for local or systemic use, comprising a therapeutically effective amount of a pharmaceutically active agent and a non-toxic, effective amount of penetration enhancing agent of the formula I: STR1 wherein R is a saturated or unsaturated, straight or branched, cyclic or acyclic hydrocarbon group with from 1 to 19 carbon atoms, alkoxyalkyl, haloalkyl, specifically trifluoromethyl, alkoxy, amino, alkylamino and acylamino; R' and R" are hydrogen, alkyl, trifluoromethyl, alkoxyalkyl, aminoalkyl, alkyl- and acylaminoalkyl, carboxy, carbalkoxy, hydroxyalkyl or lower alkyl ester thereof; X is O or NR1 wherein R1 is hydrogen, alkyl, alkenyl, alkoxyalkyl, carbalkoxyalkyl, aminoalkyl, alkyl- and acylaminoalkyl, hydroxyalkyl or hydroxyalkyloxyalkyl and lower alkyl ester thereof; and n is 2 or 3 are disclosed.
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- Compositions and method comprising heterocyclic compounds containing two heteroatoms
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A method and compositions for topically administering physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for systemic use or to the skin of humans and animals for localized use comprising applying to such skin or membrane a mixture of said physiologically active agent and a non-toxic, effective penetrating amount of penetration enhancing compound having the structural formula I: STR1 wherein: R is a saturated or unsaturated hydrocarbon group with from 5 to 19 carbon atoms; R' and R" are hydrogen, lower alkyl, trifluoromethyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl, with the proviso that both R' and R" are not lower hydroxyalkyl; X is O or NR1 ; R1 being hydrogen, lower alkyl, lower alkenyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl are disclosed.
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- Rapid Synthesis and Interconversions of Fatty 4,5-Dihydroimidazoles and Fatty 1,4,5,6-Tetrahydropyrimidines. Thermal Cyclizations of Fatty Amides Involving Phenyl Phosphorodiamidate
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Brief heating of ethane-1,2- and propane-1,3-bis-fatty amides at 235-250 deg C with phenyl phosphorodiamidate gave routes to high yields of 2-fatty alkyl-4,5-dihydroimidazoles and 1,4,5,6-tetrahydropyrimidines.Ready interconversions of fatty dihydroimidazoles and tetrahydropyrimidines, involving diamine exchange with solvent, were observed on brief heating of these materials in ethylenediamine and trimethylenediamine as solvents.
- Butler, Richard N.,Thornton, John D.,O'Regan, C.B.
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p. 2197 - 2200
(2007/10/02)
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- Amino-phosphonic-sulfonic acids
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This invention relates to compounds characterized by the presence of N-methyl, or substituted methyl, phosphonic acid and N-propylenesulfonic acid groups. These compounds contain at least one or more of each group and are bonded to the same or different amino groups. They are derived by reacting an amine with both propane sultone and with a carbonyl compound, such as formaldehyde, and phosphorous acid or its equivalent. They have a wide variety of uses, for example as scale and corrosion inhibitors, chelating agents, etc.
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