104500-98-3

Basic information

• Product Name: 1H-Pyrrole-3-carboxaldehyde,1-(2-propynyl)-(9CI)
• Synonyms: 1H-Pyrrole-3-carboxaldehyde,1-(2-propynyl)-(9CI)
• CAS NO: 104500-98-3
• Molecular Formula: C8H7NO
• Molecular Weight: 133.149
• Product Categories: AMINETERTIARY
• Mol File: 104500-98-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-3-carboxaldehyde,1-(2-propynyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxaldehyde,1-(2-propynyl)-(9CI)(104500-98-3)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxaldehyde,1-(2-propynyl)-(9CI)(104500-98-3)

Safety Data

• Hazardous Substances Data: 104500-98-3(Hazardous Substances Data)

Upstream product

• 7126-39-8 pyrrole-3-carboxaldehyde 
• 106-96-7 propargyl bromide 

Relevant articles and documents

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker

Target-identification phenotypic screening has been a powerful approach in drug discovery; however, it is hindered by difficulties in identifying the underlying cellular targets. To address this challenge, we have combined phenotypic screening of a fully functionalized small-molecule library with competitive affinity-based proteome profiling to map and functionally characterize the targets of screening hits. Using this approach, we identified ANXA2, PDIA3/4, FLAD1, and NOS2 as primary cellular targets of two bioactive molecules that inhibit cancer cell proliferation. We further demonstrated that a panel of probes can label and/or image annexin A2 (a cancer biomarker) from different cancer cell lines, thus providing opportunities for potential cancer diagnosis and therapy.

Novel pyrrole derivatives

Novel pyrrole derivatives of the formula STR1 wherein one of R2 and R3 is STR2 and the other of R2 and R3 as well as R4 and R5 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 18 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 7 to 18 carbon atoms, --CN, --CF3, --NO2, --COOAlk and Alk is alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, STR3 n is 0, 1 or 2, R', R1 ' and R2 ' are alkyl of 1 to 8 carbon atoms and R4 and R5 taken together with the carbon atoms to which they are attached may form an optionally further unsaturated carbon homocycle of up to 8 carbon atoms, Z is selected from the group consisting of hydrogen, --CN, --C CH, --CF3 and alkyl of 1 to 3 carbon atoms, A is the residue of a pyrethrinoid acid, R1 is selected from the group consisting of STR4 X', X, Y, Y' and Y" are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 8 carbon atoms and aryl of 6 to 14 carbon atoms, the dotted line indicating an optional double bond, r' is selected from the group consisting of hydrogen, alkyl of 1 to 18 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 7 to 18 carbon atoms, --CF3, --COOAlk and alkoxy of 1 to 8 carbon atoms and Alk has the above definition, R" and R'" are individually selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 6 to 18 carbon atoms, --CF3 ' --COOAlk' and alkoxy of 1 to 8 carbon atoms and Alk' is alkyl of 1 to 8 carbon atoms having pesticidal properties and novel intermediates.