104542-82-7

Basic information

• Product Name: 2-THIAZOLYL-2-THIENYL KETONE
• Synonyms: 2-THIAZOLYL-2-THIENYL KETONE;2-(2-THENOYL)THIAZOLE
• CAS NO: 104542-82-7
• Molecular Formula: C8H5NOS2
• Molecular Weight: 195.26
• Mol File: 104542-82-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-THIAZOLYL-2-THIENYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-THIAZOLYL-2-THIENYL KETONE(104542-82-7)
• EPA Substance Registry System: 2-THIAZOLYL-2-THIENYL KETONE(104542-82-7)

Safety Data

• Hazardous Substances Data: 104542-82-7(Hazardous Substances Data)

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 79265-30-8 2-(trimethylsilyl)thiazole 
• 112970-06-6 1,3-Thiazol-2-yl(2-thienyl)methanol 
• 98-03-3 thiophene-2-carbaldehyde 

Downstream Products

• 104562-44-9 (C₄H₃S)(C₃H₂NS)COB(C₆H₅)2 

Relevant articles and documents

A new and highly efficient water-soluble copper complex for the oxidation of secondary 1-heteroaryl alcohols by tert-butyl hydroperoxide

The water-soluble copper complex generated in situ from CuCl2 and 2,2′-biquinoline-4,4′-dicarboxylic acid dipotassium salt (BQC), has been revealed as a highly efficient and selective catalyst for the oxidation of secondary 1-heteroaryl alcohols to the corresponding heteroaromatic ketones with aqueous tert-butyl hydroperoxide, under mild conditions. The catalytic system is compatible with different heterocycles such as pyridines, pyrroles, indoles, thiophens, furans, thiazoles, and imidazoles.

An unusual oxidation of thiazol-2-ylmethanol in hydrolytic conditions

The treatment of aryl and heteroaryl thiazol-2-ylmethanols with sulfuric acid in a dimethoxyethane-water mixture at 80 deg C gave the corresponding ketone as the only product in good yields. All the data are agreement with a mechanism involving the format

Synthesis of (Trimethylsilyl)thiazoles and Reactions with Carbonyl Compounds. Selectivity Aspects and Synthetic Utility

Synthetic routes to all possible regioisomeric mono- and bis(trimethylsilyl)thiazoles as well as to the tris(trimethylsilyl) derivative via lithiation-silylation sequences of the thiazole ring followed by selective protodesilylation in some cases are described. (Trimethylsilyl)thiazoles serve as thiazolyl donor synthons upon reaction with carbonyl compounds (ketenes, acyl chlorides, aldehydes) for the preparation of mono- and bis-substituted thiazoles in very good yields.Carbodesilylation occurs more readily at the 2- than 5-position, whereas no reaction takes place at the 4-position.A mechanism via a thiazolium 2-ylide as an intermediate is suggested for the carbodesilylation at the 2-position.