98-03-3

Basic information

• Product Name: 2-Thenaldehyde
• Synonyms: 2-Thiophenecarboxaldehyde ,98%;2-Thiophenecarboxaldehyde,Thenaldehyde;2-Thiophenecarboxald;2-Thiophenecarboxaldehyde (stabilized with HQ);2-Formylthiophene, 2-Thenaldehyde;2-Thiophenecarboxaldehyde, 98% 100ML;THIOPHENE-2-CARBALDEHYDE FOR SYNTHESIS;2-Thiophenecarboxaldehyde 98%
• CAS NO: 98-03-3
• Molecular Formula: C5H4OS
• Molecular Weight: 112.15
• EINECS: 202-629-8
• Product Categories: Thiophen;Thiophenes & Benzothiophenes;Building Blocks;C1 to C6;C4 to C6;Carbonyl Compounds;Chemical Synthesis;Heterocyclic Building Blocks;Organic Building Blocks;aldehyde;Thiophenes;Aromatic Aldehydes & Derivatives (substituted);Aldehydes;Thiophenes & Benzothiophenes;Thiophene&Benzothiophene;Teniposide Ketotifen;Functional Materials;Reagents for Conducting Polymer Research;Thiophene Derivatives (for Conduting Polymer Research)
• Mol File: 98-03-3.mol
• Article Data: 318

Chemical Properties

• Melting Point: <10°C
• Boiling Point: 198 °C(lit.)
• Flash Point: 172 °F
• Appearance: clear yellow/liquid (clear)
• Density: 1.2 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.368mmHg at 25°C
• Refractive Index: n20/D 1.591(lit.)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• Water Solubility: insoluble
• Sensitive: Air Sensitive
• BRN: 105819
• CAS DataBase Reference: 2-Thenaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thenaldehyde(98-03-3)
• EPA Substance Registry System: 2-Thenaldehyde(98-03-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-43
• Safety Statements: 36/37/39-37-24-36-26
• RIDADR: UN 2810
• WGK Germany: 3
• RTECS: XM8135000
• F: 9
• TSCA: Yes
• Hazardous Substances Data: 98-03-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Thenaldehyde is used as a versatile building block in the synthesis of various organic compounds, particularly in the introduction of thenyl groups into target molecules. Its reactivity allows for the formation of diverse chemical structures, making it a valuable intermediate in organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Thenaldehyde is used as a key intermediate in the synthesis of β-aryl-β-amino acids and urea derivatives. These compounds are important for the development of new drugs with potential therapeutic applications.
Used as an Arylation Reagent:
2-Thenaldehyde serves as an effective arylation reagent in chemical reactions, facilitating the introduction of aryl groups into various organic substrates. This property is particularly useful in the synthesis of complex organic molecules and pharmaceutical agents.
Used in Antiviral and Cytotoxic Agent Synthesis:
2-Thenaldehyde is also utilized in the synthesis of unsaturated ketones, which have demonstrated antiviral and cytotoxic properties. These agents have potential applications in the development of new antiviral drugs and cancer therapies.

Synthesis Reference(s)

Synthesis, p. 757, 1976 DOI: 10.1055/s-1976-24193Tetrahedron Letters, 36, p. 455, 1995 DOI: 10.1016/0040-4039(94)02284-I

Purification Methods

Wash it with 50% HCl and distil it under reduced pressure just before use. It has UV: 234nm (hexane). The Z-oxime has m 144o, 136-138o and 142o (H2O). [Beilstein

InChI:InChI=1/C5H4OS/c6-4-5-2-1-3-7-5/h1-4H

Upstream product

• 1003-09-4 2-bromothiophene 
• 109-94-4 formic acid ethyl ester 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 13959-97-2 2-thiophenealdehyde diethyl acetal 
• 765-50-4 2-Chloromethylthiophene 
• 100-97-0 hexamethylenetetramine 
• 636-72-6 2-thiophenemethanol 
• 67-64-1 acetone 
• 99060-01-2 N,N-bis-[2]thienylmethyl-hydroxylamine; hydrochloride 
• 108-24-7 acetic anhydride 
• 71-43-2 benzene 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 527-72-0 2-thiophenylcarboxylic acid 
• 73927-54-5 2-ethanol 

Downstream Products

• 91259-96-0 2-(2-tienil)-3-(2-tiazolil)-4-tiazolidinone 
• 4211-92-1 2-(4-methoxy)phenyl-4-(thiophen-2-ylmethylene)-5-oxazolinone 
• 65485-87-2 1-(2-hydroxy-phenyl)-3-pyridin-3-yl-2-thiophen-2-ylmethylene-propane-1,3-dione 
• 55056-39-8 7-chloro-5-phenyl-3-thiophen-2-ylmethylene-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 70969-92-5 5-methyl-2-(4-nitro-phenyl)-4-thiophen-2-ylmethylene-2,4-dihydro-pyrazol-3-one 
• 6584-40-3 2-(thiophen-2-yl)-2,3-dihydro-1H-perimidine 
• 31404-10-1 2-[2]Thienyl-thiazolidin 
• 70733-38-9 2-(4-chloro-phenyl)-5-methyl-4-thiophen-2-ylmethylene-2,4-dihydro-pyrazol-3-one 
• 73042-94-1 2-(thiophen-2'-yl)-1H-phenanthro[9,10-d]imidazole 
• 37128-73-7 2-(2'-thienyl)-5-nitrobenzimidazole 
• 16408-55-2 4,5-diphenyl-2-(2-thienyl)-1H-imidazole 
• 93316-80-4 4,5-dioxo-1-phenyl-2-thiophen-2-yl-pyrrolidine-3-carboxylic acid ethyl ester 
• 29608-87-5 2,5-di-2-thienylthiazolo[4,5-d]thiazole 
• 56632-00-9 4-phenyl-6-thiophen-2-yl-3-(3-thiophen-2-yl-acryloyl)-1H-pyridin-2-one 

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