98-03-3

Basic information

• Product Name: 2-Thenaldehyde
• Synonyms: 2-Thiophenecarboxaldehyde ,98%;2-Thiophenecarboxaldehyde,Thenaldehyde;2-Thiophenecarboxald;2-Thiophenecarboxaldehyde (stabilized with HQ);2-Formylthiophene, 2-Thenaldehyde;2-Thiophenecarboxaldehyde, 98% 100ML;THIOPHENE-2-CARBALDEHYDE FOR SYNTHESIS;2-Thiophenecarboxaldehyde 98%
• CAS NO: 98-03-3
• Molecular Formula: C5H4OS
• Molecular Weight: 112.15
• EINECS: 202-629-8
• Product Categories: Thiophen;Thiophenes & Benzothiophenes;Building Blocks;C1 to C6;C4 to C6;Carbonyl Compounds;Chemical Synthesis;Heterocyclic Building Blocks;Organic Building Blocks;aldehyde;Thiophenes;Aromatic Aldehydes & Derivatives (substituted);Aldehydes;Thiophenes & Benzothiophenes;Thiophene&Benzothiophene;Teniposide Ketotifen;Functional Materials;Reagents for Conducting Polymer Research;Thiophene Derivatives (for Conduting Polymer Research)
• Mol File: 98-03-3.mol
• Article Data: 318

Chemical Properties

• Melting Point: <10°C
• Boiling Point: 198 °C(lit.)
• Flash Point: 172 °F
• Appearance: clear yellow/liquid (clear)
• Density: 1.2 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.368mmHg at 25°C
• Refractive Index: n20/D 1.591(lit.)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• Water Solubility: insoluble
• Sensitive: Air Sensitive
• BRN: 105819
• CAS DataBase Reference: 2-Thenaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thenaldehyde(98-03-3)
• EPA Substance Registry System: 2-Thenaldehyde(98-03-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-43
• Safety Statements: 36/37/39-37-24-36-26
• RIDADR: UN 2810
• WGK Germany: 3
• RTECS: XM8135000
• F: 9
• TSCA: Yes
• Hazardous Substances Data: 98-03-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 98-03-3 differently. You can refer to the following data:
1. Thiophene derivatives, introducing thenyl group into organic compounds.
2. 2-Thiophenecarboxaldehyde is used in the synthesis of β-aryl-β-amino acids, urea derivatives. Arylation reagent. Also used to synthesize unsaturated ketones as antiviral and cytotoxic agents.

Definition

ChEBI: An aldehyde that is thiphene substituted by a formyl group at position 2.

Synthesis Reference(s)

Synthesis, p. 757, 1976 DOI: 10.1055/s-1976-24193Tetrahedron Letters, 36, p. 455, 1995 DOI: 10.1016/0040-4039(94)02284-I

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Purification Methods

Wash it with 50% HCl and distil it under reduced pressure just before use. It has UV: 234nm (hexane). The Z-oxime has m 144o, 136-138o and 142o (H2O). [Beilstein

InChI:InChI=1/C5H4OS/c6-4-5-2-1-3-7-5/h1-4H

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 186581-53-3 diazomethane 
• 3437-95-4 2-Iodothiophene 
• 201230-82-2 carbon monoxide 
• 77735-41-2 4-O-acetyl-2,5-episeleno-3-S-ethyl-3-thio-D-arabinose diethyl dithioacetal 
• 188290-36-0 thiophene 
• 50-00-0 formaldehyd 
• 68-12-2 N,N-dimethyl-formamide 
• 93-61-8 N-methyl-N-phenylformamide 
• 1003-09-4 2-bromothiophene 
• 109-94-4 formic acid ethyl ester 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 13959-97-2 2-thiophenealdehyde diethyl acetal 
• 765-50-4 2-Chloromethylthiophene 

Downstream Products

• 140-19-2 2-<(2-thienylmethyl)amino>pyridine 
• 102241-69-0 3,3'-(thiophen-2-ylmethylene)bis(indole) 
• 81020-64-6 (Z)-3-(thiophen-2-yl)-2-(p-tolyl)acrylonitrile 
• 3783-65-1 (E)-2-(2-phenylethenyl)thiophene 
• 26440-92-6 (E)-2-phenyl-3-(2-thienyl)-2-propenoic acid 
• 10569-35-4 Z-3-(2-thienyl)-2-phenylacrylic acid 
• 37758-41-1 1-Nitro-1-phenyl-2-(2-thienyl)ethen 
• 89939-28-6 5-thiophen-2-ylmethylene-imidazolidine-2,4-dione 
• 139336-31-5 5-thiophen-2-ylmethylenethiazolidine-2,4-dione 
• 636-72-6 2-thiophenemethanol 
• 37629-59-7 (E)-2-(2-nitroprop-1-en-1-yl)thiophene 
• 24760-36-9 2-(thiophen-2-ylmethylene)indan-1,3-dione 
• 1022259-64-8 3-phenyl-4-[2]thienylmethylene-4H-isoxazol-5-one 
• 843638-98-2 2-((9H-fluorene-9-ylidene)methyl)thiophene 

Relevant articles and documents

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A “universal” catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides

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