104613-64-1

Basic information

• Product Name: 2-AMINO-4-CHLORO-5-METHYLBENZENESULFONYL CHLORIDE
• Synonyms: 2-AMINO-4-CHLORO-5-METHYLBENZENESULFONYL CHLORIDE;Benzenesulfonyl chloride,2-amino-4-chloro-5-methyl-;2-AMino-4-chloro-5-Methylbenzene-1-sulfonyl chloride
• CAS NO: 104613-64-1
• Molecular Formula: C₇H₇Cl₂NO₂S
• Molecular Weight: 240.11
• Mol File: 104613-64-1.mol

Chemical Properties

• Boiling Point: 361.855 °C at 760 mmHg
• Flash Point: 172.644 °C
• Appearance: /
• Density: 1.533 g/cm³
• Refractive Index: 1.599
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-AMINO-4-CHLORO-5-METHYLBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-CHLORO-5-METHYLBENZENESULFONYL CHLORIDE(104613-64-1)
• EPA Substance Registry System: 2-AMINO-4-CHLORO-5-METHYLBENZENESULFONYL CHLORIDE(104613-64-1)

Safety Data

• Hazardous Substances Data: 104613-64-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-4-chloro-5-methylbenzenesulfonyl chloride is used as a reagent in the synthesis of pharmaceuticals for its ability to introduce the sulfonyl chloride group, which can enhance the biological activity and pharmacological properties of drug molecules. This contributes to the development of new medications with improved efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Amino-4-chloro-5-methylbenzenesulfonyl chloride is utilized as a key intermediate in the production of agrochemicals, including pesticides and herbicides. The sulfonyl chloride group it introduces can improve the stability, selectivity, and effectiveness of these compounds in agricultural applications.
Used in Dye and Pigment Manufacturing:
2-Amino-4-chloro-5-methylbenzenesulfonyl chloride is employed as a building block in the synthesis of dyes and pigments, where the sulfonyl chloride group can impart specific color characteristics and improve the performance of these colorants in various applications, such as textiles, plastics, and printing inks.
Used in Fine Chemicals Production:
2-AMINO-4-CHLORO-5-METHYLBENZENESULFONYL CHLORIDE is also used in the manufacturing of other fine chemicals, where its sulfonyl chloride functionality can be incorporated into complex organic molecules to achieve desired chemical and physical properties, such as increased solubility, reactivity, or stability.
Safety Precautions:
Due to its high reactivity and potential to cause irritation to the skin and eyes, it is crucial to handle 2-Amino-4-chloro-5-methylbenzenesulfonyl chloride with care, using appropriate personal protective equipment and following safety guidelines to minimize health and environmental risks.

InChI:InChI=1/C7H7Cl2NO2S/c1-4-2-7(13(9,11)12)6(10)3-5(4)8/h2-3H,10H2,1H3

Upstream product

• 88-51-7 6-amino-4-chloro-meta-toluenesulfonic acid 

Downstream Products

• 5016-12-6 2-amino-4-chloro-N-methoxy-5-methyl-benzenesulfonamide 
• 5016-11-5 2-amino-4-chloro-N-hydroxy-5-methyl-benzenesulfonamide 
• 895917-83-6 (S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate 
• 132749-59-8 N-(2-bromophenyl)-4-chloro-5-methyl-2-aminobenzenesulfonamide 

Relevant articles and documents

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Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor. Optimization of various regions of the lead molecule resulted in compounds that displayed good potency and selectivity.