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N-(2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetamide Hydrobromide is a chemical compound that serves as an analogue hydrobromide salt of (S)-N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide (A618835). It plays a crucial role in the synthesis of Pramipexole (P700755), a dopamine-D2-receptor agonist and antiparkinsonian medication.

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  • N-(2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetamide Hydrobromide

    Cas No: 104617-50-7

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  • 104617-50-7 Structure
  • Basic information

    1. Product Name: N-(2-AMino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetaMide HydrobroMide
    2. Synonyms: N-(2-AMino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetaMide HydrobroMide;[N-(2-Amino-4,5,6,7- tetra hydro benzo(d) thiazol-6-yl) acetamide hydro bromide;N-(2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetamide monohydrobromide;N-(2-Amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)acetamide hydrobromide;N-[(6S)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]acetamide hydrobromide
    3. CAS NO:104617-50-7
    4. Molecular Formula: BrH*C9H13N3OS
    5. Molecular Weight: 292.19596
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 104617-50-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(2-AMino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetaMide HydrobroMide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(2-AMino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetaMide HydrobroMide(104617-50-7)
    11. EPA Substance Registry System: N-(2-AMino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetaMide HydrobroMide(104617-50-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 104617-50-7(Hazardous Substances Data)

104617-50-7 Usage

Uses

Used in Pharmaceutical Industry:
N-(2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetamide Hydrobromide is used as an intermediate in the synthesis of Pramipexole (P700755) for the treatment of Parkinson's disease. It contributes to the development of medications that target dopamine-D2 receptors, helping to alleviate symptoms associated with the condition.
Used in Research and Development:
In the field of research and development, N-(2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl)acetamide Hydrobromide is utilized as a key compound in the synthesis of various pharmaceutical products. Its role in creating Pramipexole (P700755) makes it a valuable asset for scientists and researchers working on developing new treatments for neurological disorders, particularly those related to dopamine imbalances.

Check Digit Verification of cas no

The CAS Registry Mumber 104617-50-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,6,1 and 7 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 104617-50:
(8*1)+(7*0)+(6*4)+(5*6)+(4*1)+(3*7)+(2*5)+(1*0)=97
97 % 10 = 7
So 104617-50-7 is a valid CAS Registry Number.

104617-50-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide hydrobromide

1.2 Other means of identification

Product number -
Other names 6-acetylamino-2-amino-4,5,6,7-tetrahydrobenzothiazole hydrobromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104617-50-7 SDS

104617-50-7Relevant articles and documents

IMPROVED PROCESS FOR THE PREPARATION OF (S)-2-AMINO-4,5,6,7-TETRAHYDRO-6 - (PROPYLAMINO) BENZOTHIAZOLE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

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Page/Page column 10; 12, (2011/04/13)

The present invention relates to an improved process for the preparation of of (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and its pharmaceutically acceptable salts. Specifically relates to the compound represented by the following structural formula- Ia.

PROCESS FOR PREPARING 2,6-DIAMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE

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Page 2; 5-6, (2008/06/13)

2,6-diamino-4,5,6,7-tetrahydro-benzothiazole, which is useful for making pramipexole, is made by: (i) reacting bromine with a solution of 4-acetamido-cyclohexanone in water to produce 2-bromo-4-acetamido-cyclohexanone; (ii) after step (i), adding thiourea to produce 6-acetyl amino- 2-amino-4,5,6,7-tetrahydro-benzthiazole; (iii) after step (ii), adding an aqueous solution of hydrobromic acid to produce 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole dihydrobromide; and (iv) after step (iii), isolating 2,6-diamino-4,5,6,7 -tetrahydro-benzthiazole.

Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals

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, (2008/06/13)

This invention relates to new tetrahydrobenzthiazoles of general formula STR1 wherein R1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynylk group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nuclei may each be substituted by 1 or 2 halogen atoms, R2 represents a hydrogen atom or an alkyl group, R3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by flurorine, chlorine or bromine atoms, R4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, or R3 and R4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof. The compounds of general formula I above in which one of the groups R1 or R3 or both groups R1 and R3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.

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