104632-26-0Relevant articles and documents
Preparation method of high-purity pramipexole
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, (2021/04/07)
The invention relates to the technical field of pharmacy, and provides a preparation method of high-purity pramipexole. According to the invention, raceme 2, 6-diamino 4, 5, 6, 7-tetrahydrobenzothiazole is used as an initial raw material, and pramipexole is obtained through a three-step chemical reaction, so the introduction of uncontrollable factors of drug quality is reduced, and the requirements of drug application are better met; the market price of the initial raw materials is low, so that the preparation cost of pramipexole can be greatly reduced; the solvent used in the method is green, environmentally friendly, cheap, easy to obtain and suitable for industrial production, the HPLC purity of the obtained pramipexole can reach 99.86%, and the isomer purity can reach 99.89%.
Preparation method of pramipexole
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Paragraph 0025-0032, (2020/04/17)
The invention discloses a preparation method of pramipexole. The method comprises the following steps: adding (S)-2-amino-6-propionylamino-4,5,6,7-tetrahydrobenzothiazole into tetrahydrofuran, and carrying out a reduction reaction by using a sodium borohydride/boron trifluoride complex, wherein a molar ratio of (S)-2-amino-6-propionylamino-4,5,6,7-tetrahydrobenzothiazole to sodium borohydride to boron trifluoride complex is 1:1:2-1:3:4; and separating to obtain a target product (S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole. The method provided by the invention has the advantages that the required raw materials are simple and easily available, the reaction conditions are mild, the use amount of the sodium borohydride/boron trifluoride complex is greatly reduced compared with theprior art, the reaction safety is greatly improved while the cost is saved, and the yield and the purity are higher, so that the method is suitable for industrial production.
Preparation method of pramipexole dihydrochloride and intermediate thereof
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Paragraph 0072; 0073; 0074; 0075; 0077; 0078; 0080; 0081, (2018/08/04)
The invention discloses a preparation method of pramipexole dihydrochloride and an intermediate thereof. The invention provides a preparation of pramipexole II. The preparation method of the pramipexole II comprises the following steps: performing condensation reaction and reduction reaction on a pramipexole intermediate III, propylamine and hydrogen in an organic solvent and under the existence of a chiral catalyst, and performing one-pot method to obtain the pramipexole II. According to the preparation method provided by the invention, the route step is short, chiral resolution is not neededand the total molar yield is high; furthermore, the prepared product has high purity, can reach to the standard of raw material medicines and is suitable for industrialized production. (The formula is shown in the description).