1046832-21-6

Basic information

• Product Name: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester
• Synonyms: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester;1,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1,3-DiMethyl-1H-pyrazol-4-ylboronic acid,pinacol ester;1,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1,3-Dimethyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3-DiMethylpyrazole-4-boronic acid pinacol ester;1,3-diMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1,3-dimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1,3-Dimethylpyrazole-4-boronic acid pinacol ester 97%
• CAS NO: 1046832-21-6
• Molecular Formula: C₁₁H₁₉BN₂O₂
• Molecular Weight: 222.09
• Mol File: 1046832-21-6.mol

Chemical Properties

• Melting Point: 73.0 to 77.0 °C
• Boiling Point: 322.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.04±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.56±0.10(Predicted)
• CAS DataBase Reference: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester(1046832-21-6)
• EPA Substance Registry System: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester(1046832-21-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1046832-21-6(Hazardous Substances Data)

Usage

Uses

1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester

Upstream product

• 694-48-4 1,3-dimethyl-1H-pyrazole 
• 5775-82-6 4-bromo-1,3-dimethyl-1H-pyrazole 
• 73183-34-3 bis(pinacol)diborane 
• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 936250-20-3 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 74-88-4 methyl iodide 

Downstream Products

• 1239717-41-9 C₂₇H₂₇N₅O₂ 
• 1612891-07-2 2-[(1R)-1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]-4-fluoro-N,N-dimethylbenzamide 
• 1612891-05-0 2-[(1R)-1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]-4-fluoro-N-methylbenzamide 
• 1612891-17-4 (R)-2-(1-((2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoic acid 
• 1612891-16-3 (R)-methyl 2-(1-((2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoate 
• 1616388-16-9 N-[1-(benzenesulfonyl)-2-(1,3-dimethylpyrazol-4-yl)pyrrolo[2,3-b]pyridin-5-yl]-4,5-dimethyl-1H-pyrazole-3-carboxamide 

Relevant articles and documents

Substituted heteroaryl compound and composition and application thereof

The invention provides a substituted heteroaryl compound and a pharmaceutical composition and application thereof. The compound is a compound as shown in formula (I) or the stereisomer, tautomer, nitric oxide, solvate, metabolite, pharmaceutically acceptable salt or prodrug of the compound as shown in formula (I). The pharmaceutical composition containing the compound can regulate the activity ofprotein kinase and especially the activity of Aurora kinase and JAK kinase and is used for preventing, treating and relieving diseases or disorder mediated by protein kinase and especially JAK kinase.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

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NOVEL 4-(INDOL-3-YL)-PYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE

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Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-α kinase, PDGFR-β kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases.