1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester

Base Information

• Chemical Name: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester
• CAS No.: 1046832-21-6
• Molecular Formula: C11H19BN2O2
• Molecular Weight: 222.095
• Hs Code.: 2933199090
• Mol file: 1046832-21-6.mol

Synonyms:1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester;1,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Chemical Property of 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester

Chemical Property:

• Melting Point: 73.0 to 77.0 °C
• Boiling Point: 322.3±30.0 °C(Predicted)
• PKA: 2.56±0.10(Predicted)
• PSA: 36.28000
• Density: 1.04±0.1 g/cm3(Predicted)
• LogP: 1.02770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

1,3-Dimethyl-1H-pyrazole-4-boronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester

Technology Process of 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester

There total 4 articles about 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-bromo-1,3-dimethyl-1H-pyrazole (5775-82-6) + bis(pinacol)diborane (73183-34-3) → 1,3-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (1046832-21-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield:

3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (936250-20-3,1430754-36-1) + methyl iodide (74-88-4) → 1,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1036991-40-8) + 1,3-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (1046832-21-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

Reference yield:

4-bromo-1,3-dimethyl-1H-pyrazole (5775-82-6) + 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) → 1,3-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (1046832-21-6)

Guidance literature:

4-bromo-1,3-dimethyl-1H-pyrazole; With tert.-butyl lithium; In diethyl ether; at -78 ℃; for 0.583333h; Inert atmosphere;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In diethyl ether; at -78 - 25 ℃; for 0.75h; Inert atmosphere;

upstream raw materials:

3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

methyl iodide

4-bromo-1,3-dimethyl-1H-pyrazole

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

C₂₇H₂₇N₅O₂

5-(1,3-dimethyl-1H-pyrazol-4-yl)-3-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-2-amine

N-[1-(benzenesulfonyl)-2-(1,3-dimethylpyrazol-4-yl)pyrrolo[2,3-b]pyridin-5-yl]-4,5-dimethyl-1H-pyrazole-3-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1046832-21-6 1,3-Dimethyl-1H-pyrazole-4-boronic acid,pinacol ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send