104770-18-5Relevant articles and documents
Stereocontrolled one-step synthesis of difunctionalised cispentacin derivatives through ring-opening metathesis of norbornene β-amino acids
Kiss, Lornd,Kardos, Mrton,Forr, Eniko,Fül?p, Ferenc
, p. 1283 - 1289 (2015/03/04)
Through the ring-opening metathesis of norbornene or oxanorbornene β-amino acids with ethylene in the presence of certain Ru catalysts, a facile and convenient stereocontrolled one-step method was devised for the preparation of divinylated cispentacins an
Selective mGAT2 (BGT-1) GABA uptake inhibitors: Design, synthesis, and pharmacological characterization
Vogensen, Stine B.,J?rgensen, Lars,Madsen, Karsten K.,Borkar, Nrupa,Wellendorph, Petrine,Skovgaard-Petersen, Jonas,Schousboe, Arne,White, H. Steve,Krogsgaard-Larsen, Povl,Clausen, Rasmus P.
supporting information, p. 2160 - 2164 (2013/05/08)
β-Amino acids sharing a lipophilic diaromatic side chain were synthesized and characterized pharmacologically on mouse GABA transporter subtypes mGAT1-4. The parent amino acids were also characterized. Compounds 13a, 13b, and 17b displayed more than 6-fold selectivity for mGAT2 over mGAT1. Compound 17b displayed anticonvulsive properties inferring a role of mGAT2 in epileptic disorders. These results provide new neuropharmacological tools and a strategy for designing subtype selective GABA transport inhibitors.
Stereochemical Studies, 106. - Saturated Heterocycles, 110. - Synthesis of Methylene-bridged Partially Saturated Quinazolones
Stajer, Geza,Szabo, Angela E.,Fueloep, Ferenc,Bernath, Gabor,Sohar, Pal
, p. 259 - 264 (2007/10/02)
With imidates, esters (5-8) of di-endo (1 and 2) and di-exo (3 and 4) norbornane- and norbornene-β-amino acids yield methylene-bridged tetrahydro- (18 and 20) and hexahydro-4-quinazolinones (17 and 19); the reaction of the corresponding carboxamides (9-12
Stereochemical Studies. Part 103. Saturated Heterocycles. Part 107. Preparation of 3-Mono and 2,3-Di-substituted Pyrimidin-4(3H)-ones in Retro-Diels-Alder Reactions. The Correct 1,2-Disubstituted Structure of the Compounds previously described as 2,3-Disu
Stajer, Geza,Szabo, Angela E.,Bernath, Gabor,Sohar, Pal
, p. 237 - 240 (2007/10/02)
The orthofomate cyclization of carboxamides (4) obtained from 3-exo-aminobicyclohept-5-ene-2-exo-carboxylic acid (1) yielded intermediate 8,9,10-trinorbornene-fused pyrimidinones (5) and hence 3-substituted pyrimidin-4(3H)-ones (6) through the spli
Stereochemical Studies. 81 . Saturated Heterocycles. 69 . Preparation of Methylene-bridged 3,1-Benzoxazines, 3,1-Benzoxazin-2-ones and 3,1-Benzoxazine-2-thiones
Stajer, Geza,Szabo, Angela E.,Fueloep, Ferenc,Bernath, Gabor,Sohar, Pal
, p. 1373 - 1376 (2007/10/02)
3-exo-Aminobicyclohept-5-ene-2-exo-carboxylic acid and ethyl 3-endo-aminobicycloheptane-2-endo-carboxylate (6) were reduced with lithium aluminum hydride to the corresponding bicyclic aminoalcohols 3 and 4.These and the saturated endo-endo a