The present invention encompasses compounds of general formula (I) wherein the groups R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferatio
-
Page/Page column 53
(2012/02/05)
AMINOPYRAZOLOQUINAZOLINES
Compounds of general formula (I) wherein the groups R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations whi
-
Page/Page column 21-22
(2012/09/25)
2-Chloro-1,3-dimethylimidazolinium chloride. 1. A powerful dehydrating equivalent to DCC
2-Chloro-1,3-dimethylimidazolinium chloride (DMC) (3) can act as a powerful dehydrating agent, replacing DCC (1) under nearly neutral conditions. Its application to acylation and dehydration is described.
Isobe, Toshio,Ishikawa, Tsutomu
p. 6984 - 6988
(2007/10/03)
Total synthesis and stereochemistry of alternaric acid
Determination of the stereochemistry and the total synthesis of alternaric acid 1 has been achieved. The stereostructure of 1 has been elucidated by stereoselective synthesis of four diastereoisomers of the C(9)-C(14) fragment 6, which had been obtained as a degradation product during structural studies. Key reactions of the total synthesis of 1 include the Julia olefination of tertiary aldehyde 6 and phenylsulfone 7 and novel one-pot construction of 3-acyl-4-hydroxy-5,6-dihydro-2-pyrone via Fries-type rearrangement of the O-enol acyl group of β-keto-δ-valerolactone toward the α-position of the δ-lactone. The absolute configuration of alternaric acid has been shown to be that illustrated in structure 1. The modified Fries-type rearrangement method has also been extended to the synthesis of some other compounds containing a tricarbonylmethane structure.
Tabuchi,Hamamoto,Miki,Tejima,Ichihara
p. 4749 - 4759
(2007/10/02)
METHOD OF PREPARATION OF CYCLIC β-TRIKETONES
-
Pyrko, A. N.
p. 1981 - 1982
(2007/10/02)
Process for the production of acylated 1,3-dicarbonyl compounds
An acylated 1,3-dicarbonyl compound is produced by rearrangement of the corresponding enol ester in the presence of a cyanide source. In one embodiment the cyanide source is employed with a molar excess of a moderate base, with respect to the enol ester.
-
(2008/06/13)
More Articles about upstream products of 104775-30-6