104775-30-6

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 123-62-6 propionic acid anhydride 
• 802294-64-0 propionic acid 
• 79-03-8 propionyl chloride 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 133635-98-0 2-<1-(2-naphthylamino)propylidene>cyclohexane-1,3-dione 
• 3361-72-6 1-(2,6-dihydroxyphenyl)-1-propanone 
• 25435-66-9 2-acetyl-3-chloro-2-cyclohexen-1-one 
• 55634-22-5 2-(1-Ethoxyamino-propylidene)-cyclohexane-1,3-dione 
• 55634-49-6 2-(1-Allyloxyamino-propylidene)-cyclohexane-1,3-dione 

Relevant academic research and scientific papers

NEW AMINOPYRAZOLOQUINAZOLINES

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferatio

AMINOPYRAZOLOQUINAZOLINES

Compounds of general formula (I) wherein the groups R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations whi

2-Chloro-1,3-dimethylimidazolinium chloride. 1. A powerful dehydrating equivalent to DCC

2-Chloro-1,3-dimethylimidazolinium chloride (DMC) (3) can act as a powerful dehydrating agent, replacing DCC (1) under nearly neutral conditions. Its application to acylation and dehydration is described.

Total synthesis and stereochemistry of alternaric acid

Determination of the stereochemistry and the total synthesis of alternaric acid 1 has been achieved. The stereostructure of 1 has been elucidated by stereoselective synthesis of four diastereoisomers of the C(9)-C(14) fragment 6, which had been obtained as a degradation product during structural studies. Key reactions of the total synthesis of 1 include the Julia olefination of tertiary aldehyde 6 and phenylsulfone 7 and novel one-pot construction of 3-acyl-4-hydroxy-5,6-dihydro-2-pyrone via Fries-type rearrangement of the O-enol acyl group of β-keto-δ-valerolactone toward the α-position of the δ-lactone. The absolute configuration of alternaric acid has been shown to be that illustrated in structure 1. The modified Fries-type rearrangement method has also been extended to the synthesis of some other compounds containing a tricarbonylmethane structure.

Process for the production of acylated 1,3-dicarbonyl compounds

An acylated 1,3-dicarbonyl compound is produced by rearrangement of the corresponding enol ester in the presence of a cyanide source. In one embodiment the cyanide source is employed with a molar excess of a moderate base, with respect to the enol ester.