104777-32-4

Basic information

• Product Name: Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl)
• Synonyms: Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl);Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl)- (9CI);2-Bromo-1-(3-methyl-isoxazol-5-yl)-ethanone;2-BROMO-1-(3-METHYL-5-ISOXAZOLYL) ETHANONE;2-broMo-1-(3-Methyl-1,2-oxazol-5-yl)ethan-1-one;2-bromo-1-(3-methylisoxazol-5-yl)ethanone(WXG01669)
• CAS NO: 104777-32-4
• Molecular Formula: C6H6BrNO2
• Molecular Weight: 204.02134
• Product Categories: ACETYLHALIDE
• Mol File: 104777-32-4.mol

Chemical Properties

• Melting Point: 44-46 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 281.773 °C at 760 mmHg
• Flash Point: 124.212 °C
• Appearance: /
• Density: 1.614 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.533
• PKA: -3.67±0.50(Predicted)
• CAS DataBase Reference: Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl)(104777-32-4)
• EPA Substance Registry System: Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl)(104777-32-4)

Safety Data

• Hazardous Substances Data: 104777-32-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl) is used as a key intermediate in the synthesis of pharmaceutical products. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl) serves as an important intermediate for the production of various agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural applications.
Used in Organic Synthesis:
Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl) is utilized as a versatile intermediate in organic synthesis. Its reactivity and functional groups make it a valuable building block for the creation of a wide range of organic compounds for various applications.

InChI:InChI=1/C6H6BrNO2/c1-4-2-6(10-8-4)5(9)3-7/h2H,3H2,1H3

Upstream product

• 71502-43-7 (3-methyl-5-isoxazolyl)-1-ethanol 
• 55086-61-8 5-acetyl-3-methylisoxazole 

Downstream Products

• 104777-03-9 asobamast 

Relevant articles and documents

Synthesis and pharmacological characterization of new analogs of broxaterol

A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to β1 and β2 adrenergic receptors. At variance with broxaterol, none of the tested compounds displayed agonistic activity. The 3-isopropenyl derivative 5f is the most potent antagonist both in the trachea and atria preparations.

SUBSTITUTED SULFONAMIDES AS SELECTIVE BETA-3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Substituted sulfonamides are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.

N-(4-isoxazolylthiazol-2-yl)oxamic acid derivatives as potent orally active antianaphylactic agents

A series of N-(4-isoxazolylthiazol-2-yl)oxamic acid derivatives was synthesized and tested on the passive cutaneous anaphylaxis (PCA) model in rats to verify its potential antianaphylactic activity. These compounds were prepared by reaction of an appropri

Synthesis of New Isoxazole Aminoalcohols

The preparation of new 1-isoxazolyl-2-amino-1-ethanol derivatives is described starting from the corresponding 1-isoxazolylethanones.It is also reported the synthesis of 1-(5-isoxazolyloxy)-3-amino-2-propanol compounds starting from the corresponding 5-ha