- A concise microwave-assisted synthesis of 2-aminoimidazole marine sponge alkaloids of the isonaamines series
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A short and efficient route to 1,4-substituted 2-aminoim-idazole alkaloids starting from the easily accessible 2-alkylami-nopyrimidines and α-bromo aldehydes is reported. The formation of the intermediate imidazo[l,2-a] pyrimidinium salts and subsequent cleavage were facilitated by microwave irradiation. Marine sponge alkaloids preclathridines A, C and isonaamines A, C, D were obtained in high yields using the optimized one-pot two-step procedure. Thieme Stuttgart.
- Ermolat'ev,Alifanov,Rybakov,Babaev,Van Der Eycken
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experimental part
p. 2083 - 2088
(2009/04/03)
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