Base-promoted cascade C-C coupling/N-α-sp3C-H hydroxylation for the regiospecific synthesis of 3-hydroxyisoindolinones
A base-promoted cascade reaction for the regiospecific synthesis of substituted 3-hydroxyisoindolinones under transition-metal-free conditions is developed. The base-mediated C-C bond coupling and N-α-sp3C-H bond hydroxylation are involved in t
3-hydroxy isoindole-1-ketone derivative and preparation method thereof
The invention discloses a preparation method of a 3-hydroxy isoindole-1-ketone derivative (formula 2). A compound as shown by formula (1) is used for carrying out substitution reaction in a solvent in the presence of alkali and air to obtain the 3-hydroxy
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Paragraph 0071; 0072; 0073; 0074
(2017/11/04)
SYNTHESIS AND RING-CHAIN ISOMERISM OF N-MONOSUBSTITUTED 4-BENZOYLNICOTINAMIDES AND 3-BENZOYLISONICOTINAMIDES
4-Benzoylnicotinoyl and 3-benzoylisonicotinoyl chlorides have been foundto exist in cyclic forms (3-chloro-3-phenyl-6(or 5)-azaphthalides), and their benzylamides also occur as the cyclic forms (azaisoindolines).The tert-butylamides of both acids are obta
Valter, R. E.,Batse, A. E.,Petrova, M. V.
p. 67 - 70
(2007/10/02)
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