- Tricyclic thiazole and oxazole derivatives and pharmaceutical agents containing them
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The present invention concerns thiazolo- 2,3-a!pyrrole and oxazolo- 1,2-a!pyrrole derivatives of formula I STR1 in which HET represents a heterocyclic ring with 3-7 ring atoms which can be substituted by one, two or three residues R1 which can be the same or different, Y represents an oxygen or sulphur atom, or a SO or SO2 group, X can be an oxygen or sulphur atom, R denotes an aliphatic residue with 1-9 C-atoms which can be substituted by phenyl or denotes a phenyl ring or a carbocyclic ring with 7-15 C atoms or a heterocyclic ring system each having 5 or 6 ring atoms, in which the aforementioned phenyl rings, carbocyclic rings or heterocyclic ring system can be substituted once or several times, if desired, and R1-R5 denote hydrogen or an aliphatic residue, as well as their tautomers, enantiomers, diastereomers and physiologically tolerated salts.
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- Application of Organolithium and Related Reagents in Synthesis, Part VI . A General Study of the Lithiation of Secondary Picoline- and Isonicotine Amides
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The lithiation of secondary picoline- (1) and isonicotine-amides (2) and the subsequent reaction of the corresponding (N- and 3-)lithiated amides (3 and 4) with N,N-dimethylbenzamide towards the synthesis of the C3-benzoylated picoline (12a) an
- Epsztajn, Jan,Jozwiak, Andrzej,Czech, Krzysztof,Szczesniak, Aleksandra K.
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p. 909 - 921
(2007/10/02)
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- SYNTHESIS OF 2-AZAANTRAQUINONE AND ITS DERIVATIVES
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The acylation of benzene, toluene, and chlorobenzene with cinchomeronic acid anhydride in the presence of AlCl3, has given in each case both possible isomers of the corresponding aroylpyridine carboxylic acid.It was found that the yields of reaction products and their isomeric compositions depend on the conditions of performing the reaction.The intramolecular cyclization on the isomeric keto acids in the presence of 2percent oleum has given 2-azaanthraquinone and chlorine derivatives of it.
- Artamonov, A. A.,Shneider, T.,Baranova, N. V.
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p. 397 - 401
(2007/10/02)
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