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CAS

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105051-87-4

Minamestane is a synthetic, orally active steroid derivative that belongs to the class of drugs known as aromatase inhibitors. It is primarily used in the treatment of breast cancer, particularly in postmenopausal women, where it works by reducing the production of estrogen in the body. This is achieved by inhibiting the enzyme aromatase, which is responsible for converting androgens into estrogens. By decreasing the levels of estrogen, minamestane helps to slow down the growth and spread of breast cancer cells. Additionally, it has also been investigated for its potential use in improving fertility and treating hormone-related conditions such as endometriosis.

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  • (8r,9s,10r,13s,14s)-4-amino-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8h-cyclopenta[a]phenanthrene-3,17-dione

    Cas No: 105051-87-4

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  • 105051-87-4 Structure

  • Basic information

    1. Product Name: Minamestane
    2. Synonyms: Minamestane;4-Aminoandrosta-1,4,6-triene-3,17-dione;FCE-24928
    3. CAS NO:105051-87-4
    4. Molecular Formula: C19H23NO2
    5. Molecular Weight: 297.39
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 105051-87-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 499.4°Cat760mmHg
    3. Flash Point: 255.8°C
    4. Appearance: /
    5. Density: 1.20
    6. Vapor Pressure: 4.16E-10mmHg at 25°C
    7. Refractive Index: 1.606
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 2.86±0.60(Predicted)
    11. CAS DataBase Reference: Minamestane(CAS DataBase Reference)
    12. NIST Chemistry Reference: Minamestane(105051-87-4)
    13. EPA Substance Registry System: Minamestane(105051-87-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 105051-87-4(Hazardous Substances Data)

105051-87-4 Usage

Uses

Used in Oncology:
Minamestane is used as an aromatase inhibitor for the treatment of breast cancer, particularly in postmenopausal women. It helps to slow down the growth and spread of breast cancer cells by reducing the production of estrogen in the body.
Used in Fertility Treatment:
Minamestane is used as a potential treatment for improving fertility. It has been investigated for its potential to enhance fertility outcomes in certain cases.
Used in Hormone-Related Conditions:
Minamestane is used as a potential treatment for hormone-related conditions such as endometriosis, where hormonal imbalances may contribute to the condition's symptoms and progression.

Check Digit Verification of cas no

The CAS Registry Mumber 105051-87-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,0,5 and 1 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 105051-87:
(8*1)+(7*0)+(6*5)+(5*0)+(4*5)+(3*1)+(2*8)+(1*7)=84
84 % 10 = 4
So 105051-87-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h3-4,8,10-13H,5-7,9,20H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

105051-87-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (8R,9S,10R,13S,14S)-4-amino-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthrene-3,17-dione

1.2 Other means of identification

Product number -
Other names 4-aminoandrosta-1,4,6-trien-3,17-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105051-87-4 SDS

105051-87-4Downstream Products

105051-87-4Relevant articles and documents

Process for the preparation of 4-amino-unsaturated androstanedione derivatives

-

, (2008/06/13)

4-amino-unsaturated androstanedione derivatives provided with aromatase inhibitory activity are obtained by hydrolyzation of a corresponding compound of formula II STR1

Process for the preparation of 4-amino-androstenedione derivatives

-

, (2008/06/13)

A process for the preparation of 4-aminoandrostenediones of formula (I) STR1 and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is hydrogen and the other is hydrogen, C1 -C6 alkyl, C2 -C6 alkenyl or C2 -C6 alkynyl, and the symbol indicates that each of (x) and (y), independently, is a single bond or a double bond, comprising reacting a compound of formula (II) STR2 wherein E is a halogen atom and R1, R2, (x) and (y) each are as defined as above with ammonia.

4-amino androstendione derivatives and process for their preparation

-

, (2008/06/13)

The invention discloses 4-substituted androstendione derivatives of the following formula (I) STR1 wherein R is amino or substituted amino or azido, one of R1 and R2 is hydrogen and the other is hydrogen, alkyl, alkenyl or alkynyl, and (x) and (y) are each, independently, a single bond or a double bond. The compounds of formula (I) are useful aromatase inhibitors.

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