105175-03-9Relevant articles and documents
ONE POT SYNTHESIS OF 3-CHLORO-5-SUBSTITUTED IZOXAZOLES BY 1,3-DIPOLAR CYCLOADDITION
Ciarino, Dario,Napoletano, Mauro,Sala, Alberto
, p. 1171 - 1178 (2007/10/02)
A synthesis of 3-chloro-5-substituted isoxazoles by 1,3-dipolar cycloaddition utilizing an easy preparation of dichloroformaldoxime is reported.
Process for the preparation of 3,5-disubstituted isoxazoles
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, (2008/06/13)
A novel process for the preparation of 3-bromo- and 3-chloro-5-substituted isoxazoles is provided. Dibromo- or dichloro-formaldoxime is reacted with an excess of an 1-alkyne derivative of the formula where R is hydrogen, phenyl or 1-6 C alkyl optionally substituted by halogen, OH, OR', CHO, COR', COOR', CONH2, CONR'R" or NHCOR' where, in turn, R' and R", which may be the same or different, are a 1-6 C alkyl or haloalkyl, in the presence of (i) at least an equimolecular amount, with respect to the dibromo- or dichloro-formaldoxime, of an alkaline base selected from the class consisting of sodium and potassium carbonate and bicarbonate and (ii) an inert solvent in which the 1-alkyne is soluble at room temperature.