105193-17-7Relevant articles and documents
Palladium-catalyzed cross-couplings of unsaturated halides bearing relatively acidic hydrogen atoms with organozinc reagents
Dong, Zhibing,Manolikakes, Georg,Li, Jinshan,Knochel, Paul
experimental part, p. 681 - 686 (2009/07/25)
A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using palladium(II) acetate (1 mol%), and S-Phos (2 mol%) as catalyst without the need of prot
Palladium- and nickel-catalyzed cross-couplings of unsaturated halides bearing relatively acidic protons with organozinc reagents
Manolikakes, Georg,Munoz Hernandez, Carmen,Schade, Matthias A.,Metzger, Albrecht,Knochel, Paul
supporting information; experimental part, p. 8422 - 8436 (2009/04/11)
(Chemical Equation Presented) A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups. A similar nickel-catalyzed reaction is described. The relative kinetic basicity of organozinc compounds as well as their stability toward acidic protons is also described.