Synthesis, crystal structure, molecular docking studies and bio-evaluation of some N4-benzyl-substituted isatin-3-thiosemicarbazones as urease and glycation inhibitors
Fifteen N4-benzyl-substituted isatin-3-thiosemicarbazones 5a-o were synthesized and evaluated for their urease and glycation inhibitory potential. Lemna aequinocitalis growth and Artemia salina assays were also done to determine their phytotoxi
Pervez, Humayun,Khan, Nazia,Iqbal, Jamshed,Zaib, Sumera,Yaqub, Muhammad,Tahir, Muhammad Nawaz,Naseer, Muhammad Moazzam
p. 51 - 58
(2018/02/06)
Synthesis and in vitro bio-activity evaluation of N4-benzyl substituted 5-chloroisatin- 3-thiosemicarbazones as urease and glycation inhibitors
A series of fifteen N4-benzyl substituted 5-chloroisatin-3-thiosemicarbazones 5a-o were synthesized and screened mainly for their antiurease and antiglycation effects. Lemna aequinocitalis growth and Artemia salina assays were carried out to de
Pervez, Humayun,Khan, Nazia,Iqbal, Jamshed,Zaib, Sumera,Yaqub, Muhammad,Naseer, Muhammad Moazzam
p. 108 - 118
(2018/03/29)
HINDERED DISULFIDE DRUG CONJUGATES
The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.
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Page/Page column 127; 140
(2017/05/02)
Synthesis, X-ray molecular structure, biological evaluation and molecular docking studies of some N4-benzyl substituted 5-nitroisatin-3-thiosemicarbazones
A series of fifteen N4-benzyl substituted 5-nitroisatin-3-thiosemicarbazones 5a–o was synthesized and evaluated for urease inhibitory, phytotoxic and cytotoxic influences. All the compounds proved to be highly potent inhibitors of the enzyme, s
Pervez, Humayun,Khan, Nazia,Zaib, Sumera,Yaqub, Muhammad,Naseer, Muhammad Moazzam,Tahir, Muhammad Nawaz,Iqbal, Jamshed
p. 1022 - 1029
(2017/02/05)
SURFUR-CONTAINING ALKALOIDS WITH ANTI-INFLAMMATORY ACTIVITY AND METHOD OF SYNTHESIS
The extract from Bretschneidera sinensis, surfur-containing alkaloids disclosed in the present aspects have characterized by presented pharmaceutics, cosmetics and foods having functions to improve anti-inflammatory activity.
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Paragraph 0059; 0060; 0074; 0077
(2017/05/16)
Dopamine-β-hydroxylase inhibitors and use thereof
The compounds of this invention are 1-phenylalkyl-2-mercaptotetrazole compounds which are dopamine-β-hydroxylase inhibitors.
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(2008/06/13)
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