- Synthesis of unsymmetrical 4-oxo-2-vinyl-4H-chromene-3-carbonitrile dyes via Knoevenagel reaction
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New 4-oxo-2-vinyl-4H-chromene-3-carbonitrile derivatives have been synthesized by the Knoevenagel reaction of 2-methyl-4-oxo-4H-chromene-3-carbonitrile with aromatic and heteroaromatic aldehydes. Spectral properties of the obtained compounds have been studied.
- Levchenko,Chudov,Zinoviev,Lyssenko,Demin,Poroshin,Shmelin,Grebennikov
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- Tumor-targeted hypoxic azo aromatic nitrogen oxide-chloroethyintrosoureas coupled molecule, preparation method and application thereof
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The invention provides a tumor-targeted hypoxic azo aromatic nitrogen oxide-chloroethyintrosoureas coupled molecule, a preparation method and application thereof. The coupled molecule has a structureshown as the general formula (I) in the specification, wherein R is one of OH, NH2, N(CH3)2, NHCH3, N(CH2CH3)2, and NHCH2CH3; R1 is one of H, CH3, OCH3, NO2, Cl and Br; and n is an integer of 2-6. Theazo aromatic nitrogen oxide-chloroethyintrosoureas coupled molecule provided by the invention can play a cytotoxic role and an AGT inhibitor role in low oxygen areas, and inhibit the growth of tumorcells, and also has the characteristics of hypoxia targeting, tumor resistance, drug tolerance resistance, antiangiogenesis and the like.
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Paragraph 0074; 0075; 0076
(2018/09/20)
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- Facile syntheses of 2-substituted 3-cyanochromones
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A simple and general route to 3-cyanochromones containing various substituents on position 2 of the ring is developed. The method is based on condensation of 3-(2-hydroxyphenyl)-3-oxopropionitrile with acid chlorides or anhydrides in pyridine at room temp
- Levchenko,Semenova,Yarovenko,Shmelin,Krayushkin
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p. 3630 - 3632
(2012/09/22)
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- Reactions of 3-(polyfluoroacyl)chromones with hydroxylamine: synthesis of novel RF-containing isoxazole and chromone derivatives
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Reaction of 3-(polyfluoroacyl)chromones with hydroxylamine free base proceeds via nucleophilic 1,4-addition followed by opening of the pyrone ring and subsequent cyclization to 4-(polyfluoroalkyl)-4H-chromeno[3,4-d]isoxazol-4-ols in good yields. On treatm
- Sosnovskikh, Vyacheslav Ya.,Moshkin, Vladimir S.,Kodess, Mikhail I.
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p. 7877 - 7889
(2008/12/21)
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- BETA-ADRENERGIC BLOCKING AGENTS IN THE 1,2,3-THIADIAZOLE SERIES
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Novel 4-2,3 or 4(3-amino-2-hydroxypropoxy) phenyl!-and 5-2, 3 or 4(3-amino-2-hydroxypropoxy) phenyl!-1,2,3-thiadiazole derivatives which may be further substituted at the C-5 or C-4 position of the thiadiazole ring, respectively, by a lower alkyl, phenyl, trifluoromethyl, carboxy, alkoxycarbonyl, cyano or an aminocarbonyl group, and the pharmaceutically acceptable acid addition salts thereof and processes for the production of such compounds; 4-4(3-t-butylamino-2-hydroxypropoxy) phenyl!-1,2,3-thiadiazole and 5-4(3-t-butylamino-2-hydroxypropoxy) phenyl!-1,2,3-thiadiazole are representative of the class. These compounds possess cardiovascular activity and are useful for the treatment of abnormal heart conditions in mammals.
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