10523-47-4

Basic information

• Product Name: 2-HYDROXYBENZOYLACETONITRILE
• Synonyms: 2-HYDROXYBENZOYLACETONITRILE;3-(2-HYDROXY-PHENYL)-3-OXO-PROPIONITRILE
• CAS NO: 10523-47-4
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Mol File: 10523-47-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 108-109 °C(Solv: ethanol (64-17-5))
• Boiling Point: 332.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.246±0.06 g/cm3(Predicted)
• PKA: 6.83±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXYBENZOYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYBENZOYLACETONITRILE(10523-47-4)
• EPA Substance Registry System: 2-HYDROXYBENZOYLACETONITRILE(10523-47-4)

Safety Data

• Hazardous Substances Data: 10523-47-4(Hazardous Substances Data)

Usage

General Description

2-Hydroxybenzoylacetonnitrile, also known as salicyloylacetonnitrile, is a chemical compound with the molecular formula C10H8NO2. It is a white solid at room temperature and is soluble in organic solvents. 2-HYDROXYBENZOYLACETONITRILE is used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It has been studied for its potential pharmacological activities and is known to possess anti-inflammatory and analgesic properties. 2-Hydroxybenzoylacetonnitrile has also been investigated for its potential use as a precursor in the synthesis of other biologically active compounds.

Upstream product

• 61348-47-8 5-(2-hydroxyphenyl)isoxazole 
• 6722-08-3 2-Imino-4-hydroxy-cumarin 
• 917373-44-5 4-oxo-2-(trifluoromethyl)-4H-chromene-3-carbonitrile 
• 106129-86-6 1-(2-hydroxyphenyl)-3-dimethylaminoprop-2-enone 
• 118-93-4 o-hydroxyacetophenone 
• 75-05-8 acetonitrile 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 66665-80-3 2-hydroxy-ω-formylacetophenone aldoxime 

Downstream Products

• 59899-13-7 2-(5-amino-isoxazol-3-yl)-phenol 
• 1384106-91-5 2-(4-fluoro-phenyl)-4-oxo-4H-chromene-3-carbonitrile 
• 1384106-89-1 2-(2-chlorophenyl)-4-oxo-4H-chromene-3-carbonitrile 
• 4198-00-9 4-oxo-2-phenyl-4H-chromene-3-carbonitrile 
• 1384106-92-6 4-oxo-2-o-tolyl-4H-chromene-3-carbonitrile 
• 1384106-90-4 2-(2-fluorophenyl)-4-oxo-4H-chromene-3-carbonitrile 
• 1384106-94-8 2-benzyl-4-oxo-4H-chromene-3-carbonitrile 

Relevant articles and documents

Synthesis of unsymmetrical 4-oxo-2-vinyl-4H-chromene-3-carbonitrile dyes via Knoevenagel reaction

New 4-oxo-2-vinyl-4H-chromene-3-carbonitrile derivatives have been synthesized by the Knoevenagel reaction of 2-methyl-4-oxo-4H-chromene-3-carbonitrile with aromatic and heteroaromatic aldehydes. Spectral properties of the obtained compounds have been studied.

Facile syntheses of 2-substituted 3-cyanochromones

A simple and general route to 3-cyanochromones containing various substituents on position 2 of the ring is developed. The method is based on condensation of 3-(2-hydroxyphenyl)-3-oxopropionitrile with acid chlorides or anhydrides in pyridine at room temp

Ring transformation of chromones into 4-hydroxycoumarins

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