10523-47-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxybenzoylacetonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its role in creating compounds with potential therapeutic applications. Its presence in the synthesis process aids in the development of new drugs with desired medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Hydroxybenzoylacetonitrile is utilized as a building block for the preparation of agrochemicals, contributing to the development of effective compounds for agricultural use, such as pesticides and herbicides.
Used in Organic Synthesis:
2-Hydroxybenzoylacetonitrile is used as a synthetic building block for the preparation of a wide range of organic compounds, facilitating the creation of new chemical entities with potential applications in various fields.
Used in Research and Development:
2-Hydroxybenzoylacetonitrile is employed as a subject of research for its potential pharmacological activities, including its anti-inflammatory and analgesic properties. This research is crucial for understanding and harnessing its therapeutic potential.
Used as a Precursor in Synthesis:
2-Hydroxybenzoylacetonitrile is used as a precursor in the synthesis of other biologically active compounds, indicating its importance in the development of novel chemical entities with specific biological functions.

Upstream product

• 61348-47-8 5-(2-hydroxyphenyl)isoxazole 
• 6722-08-3 2-Imino-4-hydroxy-cumarin 
• 66665-80-3 2-hydroxy-ω-formylacetophenone aldoxime 
• 106129-86-6 1-(2-hydroxyphenyl)-3-dimethylaminoprop-2-enone 
• 118-93-4 o-hydroxyacetophenone 
• 75-05-8 acetonitrile 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 917373-44-5 4-oxo-2-(trifluoromethyl)-4H-chromene-3-carbonitrile 

Downstream Products

• 59899-13-7 2-(5-amino-isoxazol-3-yl)-phenol 
• 1384106-91-5 2-(4-fluoro-phenyl)-4-oxo-4H-chromene-3-carbonitrile 
• 1384106-89-1 2-(2-chlorophenyl)-4-oxo-4H-chromene-3-carbonitrile 
• 4198-00-9 4-oxo-2-phenyl-4H-chromene-3-carbonitrile 
• 1384106-92-6 4-oxo-2-o-tolyl-4H-chromene-3-carbonitrile 
• 1384106-90-4 2-(2-fluorophenyl)-4-oxo-4H-chromene-3-carbonitrile 
• 1384106-94-8 2-benzyl-4-oxo-4H-chromene-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of unsymmetrical 4-oxo-2-vinyl-4H-chromene-3-carbonitrile dyes via Knoevenagel reaction

New 4-oxo-2-vinyl-4H-chromene-3-carbonitrile derivatives have been synthesized by the Knoevenagel reaction of 2-methyl-4-oxo-4H-chromene-3-carbonitrile with aromatic and heteroaromatic aldehydes. Spectral properties of the obtained compounds have been studied.

Tumor-targeted hypoxic azo aromatic nitrogen oxide-chloroethyintrosoureas coupled molecule, preparation method and application thereof

The invention provides a tumor-targeted hypoxic azo aromatic nitrogen oxide-chloroethyintrosoureas coupled molecule, a preparation method and application thereof. The coupled molecule has a structureshown as the general formula (I) in the specification, wherein R is one of OH, NH2, N(CH3)2, NHCH3, N(CH2CH3)2, and NHCH2CH3; R1 is one of H, CH3, OCH3, NO2, Cl and Br; and n is an integer of 2-6. Theazo aromatic nitrogen oxide-chloroethyintrosoureas coupled molecule provided by the invention can play a cytotoxic role and an AGT inhibitor role in low oxygen areas, and inhibit the growth of tumorcells, and also has the characteristics of hypoxia targeting, tumor resistance, drug tolerance resistance, antiangiogenesis and the like.

Facile syntheses of 2-substituted 3-cyanochromones

A simple and general route to 3-cyanochromones containing various substituents on position 2 of the ring is developed. The method is based on condensation of 3-(2-hydroxyphenyl)-3-oxopropionitrile with acid chlorides or anhydrides in pyridine at room temp

Reactions of 3-(polyfluoroacyl)chromones with hydroxylamine: synthesis of novel RF-containing isoxazole and chromone derivatives

Reaction of 3-(polyfluoroacyl)chromones with hydroxylamine free base proceeds via nucleophilic 1,4-addition followed by opening of the pyrone ring and subsequent cyclization to 4-(polyfluoroalkyl)-4H-chromeno[3,4-d]isoxazol-4-ols in good yields. On treatm

BETA-ADRENERGIC BLOCKING AGENTS IN THE 1,2,3-THIADIAZOLE SERIES

Novel 4-2,3 or 4(3-amino-2-hydroxypropoxy) phenyl!-and 5-2, 3 or 4(3-amino-2-hydroxypropoxy) phenyl!-1,2,3-thiadiazole derivatives which may be further substituted at the C-5 or C-4 position of the thiadiazole ring, respectively, by a lower alkyl, phenyl, trifluoromethyl, carboxy, alkoxycarbonyl, cyano or an aminocarbonyl group, and the pharmaceutically acceptable acid addition salts thereof and processes for the production of such compounds; 4-4(3-t-butylamino-2-hydroxypropoxy) phenyl!-1,2,3-thiadiazole and 5-4(3-t-butylamino-2-hydroxypropoxy) phenyl!-1,2,3-thiadiazole are representative of the class. These compounds possess cardiovascular activity and are useful for the treatment of abnormal heart conditions in mammals.