- A Convenient and Practical Synthesis of Aminopyrazoles
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A selective methodology for preparing highly substituted aminopyrazoles has been demonstrated. Starting with an acetophenol core, the corresponding substituted isoxazole is prepared in two steps. The isoxazole is transformed into a benzopyran. Alkylation
- Mitchell, David,Luo, Yumei,Mcnulty, Lu Anne M.,Buser, Jonas Y.,Mcfarland, Adam D.
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p. 235 - 241
(2015/05/05)
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- Pyrazolotriazines as inhibitors of nucleases
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The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
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Paragraph 0122; 0123; 0124; 0125; 0126; 0127; 0176-0179
(2016/01/12)
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